54476-11-8

Basic information

• Product Name: 2-(tricyclo[3.3.1.1~3,7~]dec-1-ylsulfanyl)pyridine
• CAS NO: 54476-11-8
• Molecular Formula: C₁₅H₁₉NS
• Molecular Weight: 245.3831
• Mol File: 54476-11-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 375.7°C at 760 mmHg
• Flash Point: 181°C
• Density: 1.18g/cm³
• Vapor Pressure: 1.65E-05mmHg at 25°C
• Refractive Index: 1.619
• CAS DataBase Reference: 2-(tricyclo[3.3.1.1~3,7~]dec-1-ylsulfanyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(tricyclo[3.3.1.1~3,7~]dec-1-ylsulfanyl)pyridine(54476-11-8)
• EPA Substance Registry System: 2-(tricyclo[3.3.1.1~3,7~]dec-1-ylsulfanyl)pyridine(54476-11-8)

Safety Data

• Hazardous Substances Data: 54476-11-8(Hazardous Substances Data)

Usage

Molecular Structure

2-(tricyclo[3.3.1.1^3,7^]dec-1-ylsulfanyl)pyridine consists of a tricyclic ring system and a pyridine ring attached to a sulfur atom.

Uniqueness

The compound has a unique molecular structure, which may lead to interesting properties and potential applications.

Tricyclic Ring System

The compound contains a tricyclic ring system (three interlocking rings), which contributes to its complex structure.

Pyridine Ring

A pyridine ring is present in the compound, which is a six-membered aromatic heterocyclic ring containing five carbon atoms and one nitrogen atom.

Sulfur Atom Attachment

The pyridine ring is attached to a sulfur atom, which may influence the compound's reactivity and interactions with other molecules.

Potential Applications

2-(tricyclo[3.3.1.1^3,7^]dec-1-ylsulfanyl)pyridine may have potential applications in medicinal chemistry or as a molecular probe due to its complex structure.

Interactions with Biological Systems

The compound's potential interactions with biological systems make it a promising candidate for further research in the field of medicinal chemistry.

Need for Further Research

More research is needed to fully understand the properties and potential uses of 2-(tricyclo[3.3.1.1^3,7^]dec-1-ylsulfanyl)pyridine, as its complex structure may lead to new discoveries and applications.

Upstream product

• 91233-19-1 1-(adamantane-1-carbonyloxy)pyridine-2(1H)-thione 
• 79-06-1 2-propenamide 
• 3811-73-2 2-mercaptopyridine-1-oxide sodium salt 
• 2094-72-6 1-Adamantanecarbonyl chloride 
• 79-35-6 1,1'-dichloro-2,2'-difluoroethene 
• 73899-14-6 3-phenyl-3-(trifluoromethyl)-3H-diazirine 
• 28975-80-6 Phenyl-propenyl-sulfon 

Downstream Products

• 5683-33-0 2-(Dimethylamino)pyridine 
• 5957-90-4 4-(2-pyridinyl)anisole 
• 142-08-5 2-hydroxypyridin 
• 66318-88-5 2-(2-naphthyl)pyridine 
• 4783-78-2 2-(o-tolyloxy)pyridine 
• 581-50-0 2,3'-bipyridine 

Relevant articles and documents

Chloroform as a hydrogen atom donor in barton reductive decarboxylation reactions

The utility of chloroform as both a solvent and a hydrogen atom donor in Barton reductive decarboxylation of a range of carboxylic acids was recently demonstrated (Ko, E. J. et al. Org. Lett. 2011, 13, 1944). In the present work, a combination of electronic structure calculations, direct dynamics calculations, and experimental studies was carried out to investigate how chloroform acts as a hydrogen atom donor in Barton reductive decarboxylations and to determine the scope of this process. The results from this study show that hydrogen atom transfer from chloroform occurs directly under kinetic control and is aided by a combination of polar effects and quantum mechanical tunneling. Chloroform acts as an effective hydrogen atom donor for primary, secondary, and tertiary alkyl radicals, although significant chlorination was also observed with unstrained tertiary carboxylic acids.

A facile preparation method for α,α-difluoroalkanecarboxylic acids and esters. A formal difluoromethylene insertion to alkanecarboxylic acids using radical reaction

Various alkyl radicals generated by the photoreaction of a series of Barton esters reacted with 1,1-dichloro-2,2-difluoroethene to give radical adducts as the major product accompanied with self-trapping products. Primary, secondary, tertiary, benzyl, and some unsaturated alkyl radicals as well as those with another functional group such as ether, carbonyl, and azide were applicable. Barton esters of diacids also afford 1:2 adducts with a small amount of 1:1 adducts and bis-self-trapping products except for the succinic case. These adducts were hydrolyzed with AgNO3/H2O-THF to α,α-difluoroalkanecarboxylic acids and methanolyzed with AgNO3/MeOH to the corresponding methyl esters. 4-Azido-2,2-difluorobutylic acid and the methyl ester were converted to difluoro-GABA and difluoro-γ-lactams.

Nitrogen Transfer to Carbon Radicals

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