5451-55-8 Usage
Description
4-TERT-BUTYLCYCLOHEXANECARBOXYLIC ACID is an organic compound that exists in two stereoisomeric forms. It is characterized by its white, fine crystalline structure and has been studied for its delta pKa between the stereoisomers using 1H and 13C NMR. The preparation of both cisand trans-4-tert-butylcyclohexanecarboxylic acid has been reported.
Uses
Used in Pharmaceutical Industry:
4-TERT-BUTYLCYCLOHEXANECARBOXYLIC ACID is used as a reactant for the preparation of N-((S)-3-(4-(7-chloroquinolin-4-yl)piperazin-1-yl)-1-henylpropyl)-4-tert-butylcyclohexanecarboxamide, which is a compound with potential pharmaceutical applications.
Used in Enzyme Inhibition:
In the field of biochemistry and drug development, 4-TERT-BUTYLCYCLOHEXANECARBOXYLIC ACID is used as a reactant in the synthesis of cycloalkylamide derivatives. These derivatives serve as inhibitors of soluble epoxide hydrolase, an enzyme that plays a role in various biological processes and diseases. By inhibiting this enzyme, the cycloalkylamide derivatives may have therapeutic potential in treating conditions related to the dysregulation of soluble epoxide hydrolase.
Check Digit Verification of cas no
The CAS Registry Mumber 5451-55-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,4,5 and 1 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 5451-55:
(6*5)+(5*4)+(4*5)+(3*1)+(2*5)+(1*5)=88
88 % 10 = 8
So 5451-55-8 is a valid CAS Registry Number.
InChI:InChI=1/C11H20O2/c1-11(2,3)9-6-4-8(5-7-9)10(12)13/h8-9H,4-7H2,1-3H3,(H,12,13)
5451-55-8Relevant articles and documents
Study on the enolization of alkyl of cis and trans 2-tert-5-X-1,3-dioxanes (X =CO2CH3, CHO, COPh, NO2, and CN). Evidence for stereoelectronic control.
Nbidwami, Alexis,Deslongchamps, Pierre
, p. 1788 - 1794 (2007/10/02)
Alkylation ot 2-tert-butyl-5-X-1,3-dioxanes (X = CO2CH3,COPh and NO2) was studied.Products resulting from an equatorial approach of the alkylating agent are preferentially formed when X = CO2CH3 and NO2.Also, the cis isomers that have an equatorial hydrog
Stereochemistry of Decarbalkoxylation of Cyclic Geminal Diesters Effected by Water and Lithium Chloride in Me2SO
Krapcho, A. Paul,Weimaster, John F.
, p. 4105 - 4111 (2007/10/02)
The stereochemical consequences of the decarbalkoxylation of cyclic geminal diesters by LiCl-H2O-Me2SO have been examined.The norbornene diester 13 and the norbornane diester 16 lead predominantly to the exoesters 14 and 17, respectively.The 2-methylcyclohexane diester 22 leads to esters containing more cis (23) than trans (24) isomer.The diesters 19,25, and 28 lead to nearly equal amounts of the cis and trans esters.In these latter cases,the enolates generated from the esters (via LDA) are protonated in a nonstereoselective fashion on quenching with water.This is suggestive of an enolate intermediate in the decarbalkoxylation reaction.The implications of these sterochemical results are discussed.
