54672-14-9

Basic information

• Product Name: 2-(DiMethylaMino)benzotrifluoride
• Synonyms: N,N-Dimethyl-2-trifluoromethylaniline
• CAS NO: 54672-14-9
• Molecular Formula: C₉H₁₀F₃N
• Molecular Weight: 189.1776096
• Mol File: 54672-14-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 188.7 °C at 760 mmHg
• Flash Point: 67.9 °C
• Appearance: /
• Density: 1.175 g/cm³
• Refractive Index: 1.46
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(DiMethylaMino)benzotrifluoride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(DiMethylaMino)benzotrifluoride(54672-14-9)
• EPA Substance Registry System: 2-(DiMethylaMino)benzotrifluoride(54672-14-9)

Safety Data

• Hazardous Substances Data: 54672-14-9(Hazardous Substances Data)

Usage

General Description

2-(Dimethylamino)benzotrifluoride is a chemical compound that belongs to the class of amines and is commonly used as an intermediate in the production of pharmaceuticals and agrochemicals. It has a molecular formula of C9H10F3N and a molecular weight of 189.17 g/mol. 2-(DiMethylaMino)benzotrifluoride is a colorless liquid with a boiling point of 86-87°C and a flash point of 22°C. It is known for its strong odor and is highly flammable. Additionally, it is considered to be hazardous to human health as it can cause irritation to the skin, eyes, and respiratory system. Due to its properties and potential risks, proper handling and storage guidelines should be followed when working with 2-(Dimethylamino)benzotrifluoride.

Upstream product

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Relevant articles and documents

General catalytic methylation of amines with formic acid under mild reaction conditions

A general catalytic protocol for the methylation of amines has been developed applying, for the first time, formic acid as the C1 building block and silanes as reducing agents. A broad range of aromatic and aliphatic, both primary and secondary, amines has been converted to the corresponding tertiary amines including [N-13C]-labelled drugs in good to excellent yields under mild conditions. Methylation made easy: A general catalytic protocol for the methylation of amines has been developed applying, for the first time, formic acid as the C1 building block and silanes as reducing agents. A broad range of aromatic and aliphatic, both primary and secondary, amines has been converted to the corresponding tertiary amines, including [N-13C]-labelled drugs, in good to excellent yields at mild conditions (see scheme; dppp=(1,3-bis(diphenylphosphino)propane)).

Silver-catalysed trifluoromethylation of arenes at room temperature

A variety of heteroarenes and electron rich arenes can be trifluoromethylated at room temperature with TMSCF3, catalytic silver and PhI(OAc)2.

A new method for the synthesis of trifluoromethylating agents-Diaryltrifluoromethylsulfonium salts

A new synthetic method has been developed to prepare diaryltrifluoromethylsulfonium salts from diaryldifluorosulfuranes by the action of Me3SiCF3/F-. This reaction is the transformation of nucleophilic trifluoro-methylating reagent into electrophilic one.