54673-12-0

Basic information

• Product Name: Benzene, [2-(methoxymethoxy)ethyl]-
• CAS NO: 54673-12-0
• Molecular Formula: C10H14O2
• Molecular Weight: 166.22
• Mol File: 54673-12-0.mol
• Article Data: 32

Chemical Properties

• CAS DataBase Reference: Benzene, [2-(methoxymethoxy)ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, [2-(methoxymethoxy)ethyl]-(54673-12-0)
• EPA Substance Registry System: Benzene, [2-(methoxymethoxy)ethyl]-(54673-12-0)

Safety Data

• Hazardous Substances Data: 54673-12-0(Hazardous Substances Data)

Upstream product

• 109-87-5 Dimethoxymethane 
• 82529-79-1 4-methoxybenzyl phenethyl ether 
• 60-12-8 2-phenylethanol 
• 13057-17-5 bromethyl methyl ether 
• 103-82-2 phenylacetic acid 
• 105104-40-3 Okahara's reagent 
• 107-30-2 chloromethyl methyl ether 
• 3587-61-9 1-chloromethyl 2-phenylethyl ether 
• 124-41-4 sodium methylate 

Downstream Products

• 493-05-0 isochromane 
• 60-12-8 2-phenylethanol 
• 17376-04-4 2-phenethyl iodide 
• 103-63-9 1-phenyl-2-bromoethane 
• 1355017-07-0 C₁₇H₁₄O 
• 1338236-26-2 C₁₇H₁₄O 
• 1338236-27-3 C₁₈H₁₆O 
• 1338236-28-4 C₁₈H₁₆O 
• 1338236-29-5 C₁₈H₁₆O 
• 1338236-30-8 C₁₉H₁₈O 
• 1338236-31-9 C₁₈H₁₃F₃O 
• 1338236-32-0 C₂₀H₁₈O₃ 
• 1338236-33-1 C₁₇H₁₃FO 
• 1338236-34-2 C₁₈H₁₆O₂ 

Relevant articles and documents

Iridium-Catalyzed Enantioselective Hydrogenation of Oxocarbenium Ions: A Case of Ionic Hydrogenation

Ionic hydrogenation has not been extensively explored, but is advantageous for challenging substrates such as unsaturated intermediates. Reported here is an iridium-catalyzed hydrogenation of oxocarbenium ions to afford chiral isochromans with high enantioselectivities. A variety of functionalities are compatible with this catalytic system. In the presence of a catalytic amount of the Br?nsted acid HCl, an α-chloroether is generated in situ and subsequentially reduced. Kinetic studies suggest first-order kinetics in the substrate and half-order kinetics in the catalyst. A positive nonlinear effect, together with the half kinetic order, revealed a dimerization of the catalyst. Possible reaction pathways based on the monomeric iridium catalyst were proposed and DFT computational studies revealed an ionic hydrogenation pathway. Chloride abstraction and the cleavage of dihydrogen occur in the same step.

Enantioselective synthesis of tetrahydroisoquinoline derivatives via chiral-at-metal rhodium complex catalyzed [3+2] cycloaddition

An asymmetric [3+2] cycloaddition of C,N-cyclic azomethine imines with α,β-unsaturated 2-acyl imidazoles catalyzed by a chiral-at-metal rhodium complex has been developed. The corresponding C-1-substituted tetrahydroisoquinoline derivatives were obtained in high yields (>90%) with excellent stereoselectivities (up to 99% ee and >20?:?1 dr). The reaction can be conducted on a gram-scale using a low catalyst loading (0.5 mol%) with high yield and selectivity.

Scaffold Diversity through a Branching Double-Annulation Cascade Strategy: Iminium-Induced One-Pot Synthesis of Diverse Fused Tetrahydroisoquinoline Scaffolds

A branching double-annulation cascade (BDAC) strategy for diverse and complex fused THIQ scaffolds via a highly reactive iminium-induced one-pot double-cyclization sequence involving Pictect-Spengler-type cyclization has been developed for the first time. The salient features of this protocol are that it allows direct and rapid access to unprecedented diverse fused THIQ skeletons, is metal/catalyst free, has a cleaner reaction profile, provides good to excellent yields, and is a convenient approach. This catalyst-free domino process facilitates the double annulation with a variety of scaffold building agents via two C-N and one C-X (X = C, N, O) bond formation in a single step under uniform reaction conditions. Furthermore, we reveal an unusual dual BDAC sequence leading to N-N-linked isoquinoline dimer.