5469-44-3 Usage
Description
(2E)-N-2-[(2E)-2-(furan-2-ylmethylidene)hydrazino]-2-oxoethyl-3-phenylprop-2-enamide (non-preferred name) is a synthetic organic compound characterized by a molecular formula C19H16N4O3. It is a hydrazide derivative that features a furan ring and a phenylprop-2-enamide moiety. (2E)-N-2-[(2E)-2-(furan-2-ylmethylidene)hydrazino]-2-oxoethyl-3-phenylprop-2-enamide (non-preferred name) may hold promise for medicinal and pharmaceutical research due to its unique structural elements and potential biological activities, although further research and testing are required to ascertain its precise properties and applications.
Uses
Used in Medicinal Research:
(2E)-N-2-[(2E)-2-(furan-2-ylmethylidene)hydrazino]-2-oxoethyl-3-phenylprop-2-enamide (non-preferred name) is used as a compound of interest in medicinal research for its potential to contribute to the development of new pharmaceuticals. Its specific structural features, including the furan ring and phenylprop-2-enamide moiety, may endow it with unique biological activities that could be harnessed for therapeutic purposes.
Used in Pharmaceutical Development:
In the pharmaceutical industry, (2E)-N-2-[(2E)-2-(furan-2-ylmethylidene)hydrazino]-2-oxoethyl-3-phenylprop-2-enamide (non-preferred name) may serve as a starting point for the design and synthesis of new drugs. Its potential biological activities could be explored and optimized through medicinal chemistry approaches to create effective treatments for various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 5469-44-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,4,6 and 9 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 5469-44:
(6*5)+(5*4)+(4*6)+(3*9)+(2*4)+(1*4)=113
113 % 10 = 3
So 5469-44-3 is a valid CAS Registry Number.
5469-44-3Relevant articles and documents
The Enantioselective Dakin-West Reaction
Wende, Raffael C.,Seitz, Alexander,Niedek, Dominik,Schuler, S?ren M. M.,Hofmann, Christine,Becker, Jonathan,Schreiner, Peter R.
supporting information, p. 2719 - 2723 (2016/02/27)
Here we report the development of the first enantioselective Dakin-West reaction, yielding α-acetamido methylketones with up to 58 % ee with good yields. Two of the obtained products were recrystallized once to achieve up to 84 % ee. The employed methylimidazole-containing oligopeptides catalyze both the acetylation of the azlactone intermediate and the terminal enantioselective decarboxylative protonation. We propose a dispersion-controlled reaction path that determines the asymmetric reprotonation of the intermediate enolate after the decarboxylation.
Diastereochemical diversity of imidazoline scaffolds via substrate controlled TMSCI mediated cycloaddition of azlactones
Sharma, Vasudha,Tepe, Jetze J.
, p. 5091 - 5094 (2007/10/03)
(Chemical Equation Presented) We report herein a trimethylsilyl chloride mediated substrate controlled 1,3-dipolar cycloaddition for the diastereoselective synthesis of either syn- or anti-imidazolines. This method provides scaffolds with four points of diversity and control over two stereocenters.
ASYMMETRIC SYNTHESIS OF AMINO ACIDS VIA THE CATALYTIC REDUCTION OF SUBSTITUTED ACYLAMINOACRYLIC ACID AZLACTONE DERIVATIVES. 25. REDUCTIVE AMINOLYSIS OF 2-PHENYL- AND 2-METHYL-Δ2-OXAZOLIN-5-ONES UPON TREATMENT WITH A CHIRAL PdCl2-R-PHENYLGLYCINE
Chel'tsova, G. V.,Karpeiskaya, E. I.,Klabunovskii, E. I.
, p. 727 - 731 (2007/10/02)
We have studied the reaction of Δ2-oxazolin-5-ones with R-phenylglycine methyl ester in the presence of PdCl2; the reaction gives phenylalanine or valine dipeptide derivatives with the RS-configuration.The presence of triethylamine during the r