54766-53-9

Basic information

• Product Name: N-(3-CHLOROPHENYL)-N-METHYLACETAMIDE
• Synonyms: N-(3-CHLOROPHENYL)-N-METHYLACETAMIDE
• CAS NO: 54766-53-9
• Molecular Formula: C₉H₁₀ClNO
• Molecular Weight: 183.6348
• Mol File: 54766-53-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 280.1°C at 760 mmHg
• Flash Point: 123.2°C
• Appearance: /
• Density: 1.2g/cm³
• Vapor Pressure: 0.00386mmHg at 25°C
• Refractive Index: 1.568
• CAS DataBase Reference: N-(3-CHLOROPHENYL)-N-METHYLACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-CHLOROPHENYL)-N-METHYLACETAMIDE(54766-53-9)
• EPA Substance Registry System: N-(3-CHLOROPHENYL)-N-METHYLACETAMIDE(54766-53-9)

Safety Data

• Hazardous Substances Data: 54766-53-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H10ClNO/c1-7(12)11(2)9-5-3-4-8(10)6-9/h3-6H,1-2H3

Upstream product

• 6848-13-1 3-chloro-N,N-dimethylaniline 
• 64-19-7 acetic acid 
• 108-24-7 acetic anhydride 
• 108-42-9 3-chloro-aniline 
• 588-07-8 3-Chloroacetanilide 
• 74-88-4 methyl iodide 
• 506-96-7 Acetyl bromide 

Downstream Products

• 1173504-70-5 N-(5-chloro-2-((triisopropylsilyl)ethynyl)phenyl)-N-methylacetamide 
• 71-50-1 acetate 
• 7006-52-2 3-chloro-N-methylaniline 

Relevant articles and documents

Thermolysis and radiofluorination of diaryliodonium salts derived from anilines

Aniline-derived diaryliodonium salts were synthesized and functionalized in good to excellent yields by judicious utilization of electron-withdrawing protecting groups. This simple approach opens another route to radiolabeling amino arenes in relatively complex molecules, such as flutemetamol.

The copper-catalyzed aerobic oxidative amidation of tertiary amines

A general and efficient method for the synthesis of tertiary amides has been developed via the copper-catalyzed aerobic oxidative amidation of tertiary amines. Due to the use of the O2 oxidant, various functional groups were well tolerated under the present conditions. Extensive substrates studies demonstrated its potential as a practical approach for the synthesis of tertiary amides.

Amide bond formation through iron-catalyzed oxidative amidation of tertiary amines with anhydrides

A general and efficient method for amide bond synthesis has been developed. The method allows for synthesis of tertiary amides from readily available tertiary amines and anhydrides in the presence of FeCl2 as catalyst and tert-butyl hydroperoxide in water (T-Hydro) as oxidant. Mechanistic studies indicated that the in situ-generated α-amino peroxide of tertiary amine and iminium ion act as key intermediates in this oxidative transformation.