54779-53-2 Usage
General Description
9-aminoellipticine is a synthetic chemical compound derived from the natural alkaloid ellipticine. It has shown potential as an antitumor agent and has been studied for its ability to inhibit the growth of cancer cells. The compound functions by intercalating with DNA and disrupting the DNA replication process, leading to the inhibition of cell division and ultimately, the death of cancer cells. Its mechanism of action also includes the inhibition of topoisomerase II, an enzyme involved in DNA replication. Additionally, 9-aminoellipticine has been studied for its potential anti-inflammatory and anti-viral properties. Overall, the compound holds promise for the development of new anticancer drugs and is a subject of ongoing research in the medical and pharmaceutical fields.
Check Digit Verification of cas no
The CAS Registry Mumber 54779-53-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,7,7 and 9 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 54779-53:
(7*5)+(6*4)+(5*7)+(4*7)+(3*9)+(2*5)+(1*3)=162
162 % 10 = 2
So 54779-53-2 is a valid CAS Registry Number.
InChI:InChI=1/C17H15N3/c1-9-14-8-19-6-5-12(14)10(2)17-16(9)13-7-11(18)3-4-15(13)20-17/h3-8,20H,18H2,1-2H3
54779-53-2Relevant articles and documents
On 9-amino derivatives of ellipticine and a comparative study on DNA apurinic site cleavage and mutagenicity
Lefrancois,Lescot,Psaume,Malvy,Gansser,Virlizier,Boissart,Gauduchon
, p. 1197 - 1206 (2007/10/02)
The synthesis of 9-aminoellipticine (IV) has been improved by amination of 9-bromoellipticine according to the Goldberg reaction. Also via the Goldberg procedure we obtained 9-methylamino-ellipticine (VI) with the aim to reduce the mutagenicity of (IV). Even though 2-methyl-9-aminoellipticinium acetate (VII) has been mentioned in a previous paper, no details were given for its preparation. We therefore synthesized this compound in such a way as to obtain a monoquaternary salt where only the pyridinic nitrogen bears the positive charge. The study of cleavage induced by 10 μM of (IV) and (VII) on a plasmid DNA (PM2) containing a low concentration of apurinic sites shows that (VII) possesses the same property of cleavage at apurinic sites as (IV) and reaches almost complete cleavage despite its slower reaction rate. The quaternized derivative (VII) is not mutagenic on tested Salmonella strains in contrast with its free base (IV).
9 Hydroxyellipticine and some of its derivatives
Dat Xuong,Adeline,Lecointe,Janot
, p. 623 - 626 (2007/10/05)
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