548485-14-9Relevant articles and documents
Preparation and bioevaluation of 99mTc nitrido radiopharmaceuticals with pyrazolo[1,5-a]pyrimidine as tumor imaging agents
Ding, Rui,He, Yong,Xu, Jingli,Liu, Hang,Wang, Xiao,Feng, Man,Qi, Chuanmin,Zhang, Junbo,Peng, Cheng
experimental part, p. 523 - 530 (2012/09/07)
The 7-(2-aminoethylamino)-5-methyl-3-cyanopyrazolo[ 1,5-a]pyrimidine (AMCPP) was synthesized and conjugated with N-mercaptoacetylglycine (MAG), N-mercaptoacetylphenylalanine (MAF), and N-mercaptoacetylvaline (MAA), respectively. These three compounds were labeled successfully with [ 99mTcN]2+ intermediate in high radiochemical purities. Biodistribution in tumor-bearing mice demonstrated that the three new complexes showed high tumor-to-muscle (T/M) ratios and rapid clearance from the blood, muscle, liver, kidney, and lung. Among them, the 99mTcN-MAG-AMCPP showed the most favorable characteristics. The tumor/blood and tumor/muscle ratios reached 1.50 and 1.15 at 30 min post-injection, 2.20 and 1.83 at 60 min post-injection. Springer Science+Business Media, LLC 2011.
Synthesis of novel N3S pseudo-peptide and biodistribution of 99Tcm-pseudo-peptide complexes in mice
Qi, Chuan-Min,Yang, Ling-Chun,Zhang, Hua-Bei,Guo, Xue-Feng,Feng, Shu-Juan,Li, Bo
, p. 345 - 359 (2007/10/03)
An excellent reaction condition of active ester with amine acid was developed, and a series of novel N3S pseudo-peptide chelators starting from mercaptoacetic acid were synthesized and characterized based on the spectroscopic data, such as IR,
