552331-16-5

Basic information

• Product Name: 5-BROMO-3-METHYL-1H-INDAZOLE
• Synonyms: 5-BROMO-3-METHYL-1H-INDAZOLE;5-BROMO-3-METHYL-INDAZOLE;1H-Indazole, 5-bromo-3-methyl-;5-bromo-3-methyl-2H-indazole
• CAS NO: 552331-16-5
• Molecular Formula: C₈H₇BrN₂
• Molecular Weight: 211.06
• Product Categories: Indazole;Building Blocks
• Mol File: 552331-16-5.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 341.417 °C at 760 mmHg
• Flash Point: 160.284 °C
• Appearance: /
• Density: 1.655 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.697
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 13.13±0.40(Predicted)
• CAS DataBase Reference: 5-BROMO-3-METHYL-1H-INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-3-METHYL-1H-INDAZOLE(552331-16-5)
• EPA Substance Registry System: 5-BROMO-3-METHYL-1H-INDAZOLE(552331-16-5)

Safety Data

• Hazardous Substances Data: 552331-16-5(Hazardous Substances Data)

Usage

General Description

5-BROMO-3-METHYL-1H-INDAZOLE is a chemical compound that belongs to the family of indazoles, which are heterocyclic aromatic compounds. It is a derivative of indazole, containing a bromine atom at the 5-position and a methyl group at the 3-position. 5-BROMO-3-METHYL-1H-INDAZOLE is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It has been studied for its potential biological activities, including its role as an antiviral and antibacterial agent. Additionally, 5-BROMO-3-METHYL-1H-INDAZOLE has been investigated for its use in materials science and organic synthesis due to its unique chemical structure and reactivity.

InChI:InChI=1/C8H7BrN2/c1-5-7-4-6(9)2-3-8(7)11-10-5/h2-4H,1H3,(H,10,11)

Upstream product

• 29124-56-9 1-(2-amino-5-bromophenyl)ethanone 
• 41877-24-1 1-(5-bromo-2-nitrophenyl)ethane-1-one 
• 2142-63-4 1-(3-Bromophenyl)ethanone 
• 45762-41-2 4-bromo-2-ethylaniline 
• 93777-26-5 5-bromo-2-fluorobenzaldehyde 
• 198477-89-3 1-(5-bromo-2-fluorophenyl)ethan-1-one 
• 552331-15-4 1-(5-bromo-2-fluorophenyl)ethan-1-ol 

Downstream Products

• 552331-49-4 tert-butyl 5-bromo-3-methyl-1H-indazole-1-carboxylate 
• 267875-55-8 3-methyl-1H-indazole-5-carbonitrile 

Relevant articles and documents

THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS

Provided herein are compounds, preferably thyroid hormone receptor beta (THR beta) agonist compounds, compositions thereof, and methods of their preparation, and methods of agonizing THR beta and methods for treating disorders mediated by THR beta.

A 1H-indazole derivatives preparation method

The invention provides a method for preparing 3-methyl-5-R-1H-indazole easily, safely and efficiently without performing any hydrazine hydrate reflux heating reaction or purifying a product and making the product pass through a column. The method at least comprises the following steps of: a, performing a diazo-reaction on 2-amino-5-R-hypnone serving as a raw material or an intermediate under the condition of an acid solution to generate a diazo salt; b, slowly adding a stannous chloride-hydrate hydrochloric acid solution into the diazo salt obtained in the step a for reacting to generate a 3-methyl-5-R-1H-indazole solution; and c, cooling the solution obtained in the step b under the condition that the pH value is 8-9, and precipitating a product out, wherein R in the steps above represents H or a halogen element.

INDAZOLES

The invention provides novel substituted indazole compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases such as cancer, inflammatory or degenerative diseases.