55290-68-1 Usage
Description
Trazodone N-Oxide, also known as Trazodone impurity A, is a metabolite of Trazodone-HCl (T718500). It is characterized by its off-white solid appearance and is derived from the parent compound Trazodone-HCl, which is a pharmaceutical drug.
Uses
Used in Pharmaceutical Industry:
Trazodone N-Oxide is used as a metabolite for the study and analysis of Trazodone-HCl. As a metabolite, it plays a role in understanding the pharmacokinetics, pharmacodynamics, and potential side effects of the parent drug, Trazodone-HCl. This information is crucial for the development and optimization of drug therapies, as well as for assessing the safety and efficacy of the medication.
Used in Research and Development:
In the field of research and development, Trazodone N-Oxide is utilized as a reference compound for the identification, characterization, and quantification of impurities in the synthesis and manufacturing process of Trazodone-HCl. This helps ensure the quality, purity, and consistency of the final drug product, which is essential for its therapeutic use.
Used in Quality Control:
Trazodone N-Oxide is also used in quality control processes to verify the purity and potency of Trazodone-HCl. By comparing the properties and behavior of the metabolite with those of the parent compound, quality control professionals can ensure that the drug meets the required standards and is safe for use in patients.
Check Digit Verification of cas no
The CAS Registry Mumber 55290-68-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,2,9 and 0 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 55290-68:
(7*5)+(6*5)+(5*2)+(4*9)+(3*0)+(2*6)+(1*8)=131
131 % 10 = 1
So 55290-68-1 is a valid CAS Registry Number.
InChI:InChI=1/C19H22ClN5O2/c20-16-5-3-6-17(15-16)22-10-13-25(27,14-11-22)12-4-9-24-19(26)23-8-2-1-7-18(23)21-24/h1-3,5-8,15H,4,9-14H2
55290-68-1Relevant articles and documents
Application of the UHPLC method for separation and characterization of major photolytic degradation products of trazodone by LC-MS and NMR
Thummar, Mohit,Patel, Prinesh N.,Kushwah, Bhoopendra Singh,Samanthula, Gananadhamu
, p. 16972 - 16984 (2018)
Drug degradation products are a type of drug impurity which affects the safety of the drug products. Trazodone (TZD) is an antidepressant drug subjected to forced degradation as per ICH embedded guidelines for predicting the drug degradation products. It undergoes degradation in acidic hydrolysis, peroxide induced oxidation and upon exposure to day light and results in the formation of ten degradation products (DPs). A UHPLC method was developed to separate TZD and its DPs using the stationary phase of an Acquity UPLC CSH C18 column (100 × 2.1 mm, 1.7 μm) and a mobile phase of solvent-A (10 mM ammonium acetate, pH 8.5) and solvent-B (methanol) at a flow rate of 0.25 mL min-1 in gradient elution. This method was transferred to a quadrupole time-of-flight tandem mass spectrometer (QTOF-MS/MS) for identification of the DPs. Very interestingly, four dimer DPs were found under photolytic degradation conditions and they are found to be isomers. The major isomer (DP-10) was isolated by using preparative HPLC and its structure was identified using proton and carbon NMR. Three N-oxide DPs were also observed and the site of N-oxidation was identified by using atmospheric pressure chemical ionization mass spectrometry (APCI-MS). The developed UHPLC method was validated as described in the ICH prescribed guidelines and USP general chapter on method validation. The proposed validated stability indicating assay method can be used for identification and quantification of TZD and its DPs in a quality control lab for product release testing and stability studies of the drug in much less time with greater selectivity.
