55396-63-9

Basic information

• Product Name: 2-(2-pyridinyl)-1H-Benzimidazol-6-amine
• Synonyms: 2-(2-pyridinyl)-1H-Benzimidazol-6-amine;2-(pyridin-2-yl)-1H-1,3-benzodiazol-6-amine;2-pyridin-2-yl-1H-benzimidazol-6-amine
• CAS NO: 55396-63-9
• Molecular Formula: C₁₂H₁₀N₄
• Molecular Weight: 210.2346
• Mol File: 55396-63-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 217 °C(Solv: ethanol (64-17-5))
• Boiling Point: 511.2±48.0 °C(Predicted)
• Appearance: /
• Density: 1.348±0.06 g/cm3(Predicted)
• PKA: 10.18±0.10(Predicted)
• CAS DataBase Reference: 2-(2-pyridinyl)-1H-Benzimidazol-6-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-pyridinyl)-1H-Benzimidazol-6-amine(55396-63-9)
• EPA Substance Registry System: 2-(2-pyridinyl)-1H-Benzimidazol-6-amine(55396-63-9)

Safety Data

• Hazardous Substances Data: 55396-63-9(Hazardous Substances Data)

Usage

General Description

2-(2-pyridinyl)-1H-Benzimidazol-6-amine is a chemical compound with the molecular formula C13H10N4. It is a benzimidazole derivative with a pyridinyl group attached to the benzimidazole ring. 2-(2-pyridinyl)-1H-Benzimidazol-6-amine has potential biological and pharmaceutical applications due to its structural features and properties. It may act as a ligand for certain biomolecules, interact with cellular receptors, or exhibit antimicrobial or anti-cancer activities. Further research is needed to fully understand the potential uses and effects of 2-(2-pyridinyl)-1H-Benzimidazol-6-amine in various fields of science and medicine.

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 1121-60-4 pyridine-2-carbaldehyde 
• 1137-68-4 2-(2'-pyridyl)benzimidazole 
• 98-98-6 2-Picolinic acid 
• 51759-60-5 5-nitro-2-(pyridin-2-yl)-1H-benzo[d]imidazole 

Downstream Products

• 1112986-70-5 phenyl(2-pyridin-2-yl-3H-benzoimidazol-5-y)diazene 

Relevant articles and documents

Metal-mediated inhibition of escherichia coli methionine aminopeptidase: Structure-activity relationships and development of a novel scoring function for metal-ligand interactions

We report the discovery of thiabendazole as a potent inhibitor (K 1 = 0.4 μM) of Escherichia coli methionine aminopeptidase (ecMetAP) and the synthesis and pharmacological evaluation of thiabendazole congeners with activity in the upper nanomolar range, Elucidation of the X-ray structure of ecMetAP in complex with thiabendazole and an unrelated inhibitor that was independently described by another group showed that that both compounds bind to an additional CoII ion at the entrance of the active site. This unexpected finding explains the inactivity of the compounds under in vivo conditions. It also allows us to discuss the structure-activity relationships of this series of compounds in a meaningful way, based upon docking runs with an auxiliary metal ion, We describe a new scoring function for the evaluation of metal-mediated inhibitor binding that, unlike the previously used scoring function implemented in the docking program, allows us to distinguish between active and inactive compounds, Finally, conclusions for the structure-based design of in vivo-active inhibitors of ecMetAP are drawn.

Chemistry of 2-substituted benzimidazoles. 1. 5-Amino-2-methyl(aryl, arylalkyl, pyridyl)benzimidazoles

A series of 2-substituted benzimidazoles was synthesized. These products were consecutively converted into 5-nitro- and 5-amino-2-substituted benzimidazoles.