55400-73-2 Usage
Description
1,11-BIS(METHANESULFONYLOXY)-3,6,9-TRIOXANDECANE, also known as Ms-PEG5-Ms, is a PEG linker containing two mesyl moieties. The mesyl groups serve as good leaving groups and can also act as protecting groups for primary alcohols, which can be deprotected in the presence of sodium amalgam. 1,11-BIS(METHANESULFONYLOXY)-3,6,9-TRIOXANDECANE is characterized by its hydrophilic PEG linker, which enhances its water solubility in aqueous media. Ms-PEG5-Ms is a yellow oil.
Uses
Used in Pharmaceutical Industry:
1,11-BIS(METHANESULFONYLOXY)-3,6,9-TRIOXANDECANE is used as a protecting group for primary alcohols in the synthesis of various pharmaceutical compounds. The mesyl groups provide a stable and easily removable protection, allowing for selective reactions and increased synthetic efficiency.
Used in Chemical Synthesis:
1,11-BIS(METHANESULFONYLOXY)-3,6,9-TRIOXANDECANE is used as a PEG linker in the chemical synthesis of various molecules, including drugs, polymers, and other bioactive compounds. The hydrophilic PEG linker improves the water solubility of the resulting compounds, which can be beneficial for their biological activity, stability, and pharmacokinetic properties.
Used in Drug Delivery Systems:
1,11-BIS(METHANESULFONYLOXY)-3,6,9-TRIOXANDECANE can be used as a component in the design of drug delivery systems, such as nanoparticles or hydrogels, due to its hydrophilic nature and ability to form stable linkages with other molecules. This can lead to improved drug release profiles, targeted drug delivery, and reduced side effects.
Used in Bioconjugation:
1,11-BIS(METHANESULFONYLOXY)-3,6,9-TRIOXANDECANE can be employed as a bioconjugation agent, allowing for the attachment of biologically active molecules, such as peptides, proteins, or nucleic acids, to various surfaces or other molecules. The PEG linker can provide a flexible and hydrophilic spacer, which can be advantageous for maintaining the biological activity of the attached molecules and reducing non-specific interactions.
Check Digit Verification of cas no
The CAS Registry Mumber 55400-73-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,4,0 and 0 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 55400-73:
(7*5)+(6*5)+(5*4)+(4*0)+(3*0)+(2*7)+(1*3)=102
102 % 10 = 2
So 55400-73-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H22O9S2/c1-20(11,12)18-9-7-16-5-3-15-4-6-17-8-10-19-21(2,13)14/h3-10H2,1-2H3
55400-73-2Relevant articles and documents
A convenient route to diversely substituted icosahedral closomer nanoscaffolds
Jalisatgi, Satish S.,Kulkarni, Vikas S.,Tang, Betty,Houston, Zachary H.,Lee, Mark W.,Hawthorne, M. Frederick
supporting information; scheme or table, p. 12382 - 12385 (2011/10/02)
The design and synthesis of icosahedral polyhedral borane closomer motifs based upon carbonate and carbamate anchoring groups for biomedical applications are described. Dodecacarbamate closomers containing easily accessible groups of interest at their linker termini were synthesized via activation of the B-OH vertices as aryl carbonates and their subsequent reaction with primary amines. Novel dodecacarbonate closomers were successfully synthesized for the first time by reacting [closo-B12(OH)12]2- with an excess of respective aryl chloroformates, utilizing relatively short reaction times, mild conditions and simple purification strategies, all of which had previously presented difficulties in closomer chemistry. This methodology for the 12-fold degenerate synthesis of carbonate and carbamate closomers will greatly facilitate further exploration of closomers as monodisperse nanomolecular delivery platforms.
