55512-05-5

Basic information

• Product Name: Methanesulfonamide,N-(3-formylphenyl)-
• Synonyms: 3-(Methanesulfonamido)benzaldehyde;3-(Methanesulfonylamino)benzaldehyde;3-(Methylsulfonamido)benzaldehyde;3-[(Methylsulfonyl)amino]benzaldehyde;N-(3-Formylphenyl)methanesulfonamide
• CAS NO: 55512-05-5
• Molecular Formula: C₈H₉NO₃S
• Molecular Weight: 199.227
• Product Categories: Carbonyl Compounds
• Mol File: 55512-05-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 146 °C
• Boiling Point: 348.6 °C at 760 mmHg
• Flash Point: 164.6 °C
• Appearance: /
• Density: 1.407 g/cm³
• Vapor Pressure: 4.99E-05mmHg at 25°C
• Refractive Index: 1.605
• PKA: 7.59±0.10(Predicted)
• CAS DataBase Reference: Methanesulfonamide,N-(3-formylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanesulfonamide,N-(3-formylphenyl)-(55512-05-5)
• EPA Substance Registry System: Methanesulfonamide,N-(3-formylphenyl)-(55512-05-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Hazardous Substances Data: 55512-05-5(Hazardous Substances Data)

Usage

General Description

Methanesulfonamide, N-(3-formylphenyl)- is a chemical compound with the molecular formula C8H9NO3S. It is a white solid that is used in the synthesis of pharmaceuticals and agrochemicals. Methanesulfonamide,N-(3-formylphenyl)- is also known for its use as a reagent in organic synthesis. It is a sulfonamide derivative, which has been found to exhibit antimicrobial and antitumor activities. Methanesulfonamide, N-(3-formylphenyl)- is known for its potential use in the development of new drugs and its ability to inhibit the growth of cancer cells.

InChI:InChI=1/C8H9NO3S/c1-13(11,12)9-8-4-2-3-7(5-8)6-10/h2-6,9H,1H3

Upstream product

• 32087-05-1 3-methanesulfonylaminobenzoic acid methyl ester 
• 4518-10-9 Methyl 3-aminobenzoate 
• 376347-09-0 N-(3-hydroxymethylphenyl)methanesulfonamide 
• 124-63-0 methanesulfonyl chloride 
• 1709-44-0 m-aminobenzaldehyde 

Downstream Products

• 1059198-63-8 3-[4-(4-chlorophenoxy)phenyl]-2-(3-mesylaminophenyl)thiazolidin-4-one 
• 943410-74-0 rac-N-[3-(1-hydroxyethyl)phenyl]methanesulfonamide 
• 1353657-62-1 rac-N-[3-(1-chloroethyl)phenyl]methanesulfonamide 
• 916059-55-7 (2E,4Z)-5-(3-methanesulfonylaminophenyl)pentadienoic acid ethyl ester 
• 916059-56-8 (2E,4E)-5-(3-methanesulfonylaminophenyl)pentadienoic acid ethyl ester 
• 79406-64-7 N-[3-(2-Amino-1-hydroxy-ethyl)-phenyl]-methanesulfonamide 

Relevant articles and documents

N'-Alkylaminosulfonyl Analogues of 6-Fluorobenzylideneindolinones with Desirable Physicochemical Profiles and Potent Growth Inhibitory Activities on Hepatocellular Carcinoma

The benzylideneindolinone 6-chloro-3-(3′-trifluoromethylbenzylidene)-1,3-dihydroindol-2-one (4) was reported to exhibit potent and selective growth inhibitory effects on hepatocellular carcinoma (HCC). Corroborative evidence supported multi-receptor tyrosine kinase (RTK) inhibition as a possible mode of action. However, the poor physicochemical properties of 4 limited its furtherance as a lead compound. In this study, the modification of 4 was investigated with the aim of improving its potency and physicochemical profile. The 6-fluorobenzylideneindolinone 3-12 bearing a 3′-N-propylaminosulfonyl substituent was found to be a promising substitute. Compound 3-12 [6-fluoro-3-(3′-N-propylaminosulfonylbenzylidene)-1,3-dihydroindol-2-one] was found to be tenfold more soluble than 4 and to have sub-micromolar growth inhibitory activities on HCC cells. It is apoptogenic and inhibits the phosphorylation of several RTKs in HuH7, of which the inhibition of FGFR4 and HER3 are prominent. Compound 3-12 decreased the tumor load in a physiologically relevant orthotopic HCC xenograft murine model. Structure-activity relationships support pivotal roles for the fluoro and N′-propylaminosulfonyl moieties in enhancing cell-based activity and moderating the physicochemical profile (solubility, permeability) of 3-12.

HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS

Provided herein are Heteroaryl Compounds having the following structure: (I) wherein R1, R2, L, X, Y, Z, Q, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

HYDROXAMIC ACIDS USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS

This invention relates to a compound of Formula (I) and its use in treating hyper-proliferative disorders.