376347-09-0

Basic information

• Product Name: Methanesulfonamide, N-[3-(hydroxymethyl)phenyl]-
• Synonyms: N-(3-hydroxy methyl-phenyl)methanesulfonamide;[3-(hydroxymethyl)phenyl](methylsulfonyl)amine
• CAS NO: 376347-09-0
• Molecular Formula: C8H11NO3S
• Molecular Weight: 201.246
• Mol File: 376347-09-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Methanesulfonamide, N-[3-(hydroxymethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanesulfonamide, N-[3-(hydroxymethyl)phenyl]-(376347-09-0)
• EPA Substance Registry System: Methanesulfonamide, N-[3-(hydroxymethyl)phenyl]-(376347-09-0)

Safety Data

• Hazardous Substances Data: 376347-09-0(Hazardous Substances Data)

Usage

Description

Methanesulfonamide, N-[3-(hydroxymethyl)phenyl]is a chemical compound with the molecular formula C8H11NO3S. It is a derivative of methanesulfonamide and is characterized by a phenyl group with a hydroxymethyl substituent attached to the nitrogen atom. Methanesulfonamide, N-[3-(hydroxymethyl)phenyl]is commonly used in organic synthesis as a reagent for preparing various compounds and serves as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Its applications extend to the pharmaceutical industry for the production of drugs and medicinal products, as well as potential uses in medicinal chemistry and drug discovery.

Uses

Used in Pharmaceutical and Agrochemical Industries:
Methanesulfonamide, N-[3-(hydroxymethyl)phenyl]is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique structure allows for the development of new compounds with potential therapeutic and agricultural applications.
Used in Organic Synthesis:
In the field of organic synthesis, Methanesulfonamide, N-[3-(hydroxymethyl)phenyl]is utilized as a reagent for the preparation of a wide range of compounds. Its versatility in chemical reactions makes it a valuable component in the synthesis of complex organic molecules.
Used in Medicinal Chemistry and Drug Discovery:
Methanesulfonamide, N-[3-(hydroxymethyl)phenyl]has potential applications in medicinal chemistry and drug discovery. Its unique structure and reactivity can contribute to the development of new drugs and therapeutic agents, advancing the field of pharmaceutical research.

Upstream product

• 4518-10-9 Methyl 3-aminobenzoate 
• 32087-05-1 3-methanesulfonylaminobenzoic acid methyl ester 
• 93884-11-8 ethyl 3-(methylsulfonamido)benzoate 

Downstream Products

• 55512-05-5 m-(methylsulfonylamino)benzaldehyde 

Relevant articles and documents

N'-Alkylaminosulfonyl Analogues of 6-Fluorobenzylideneindolinones with Desirable Physicochemical Profiles and Potent Growth Inhibitory Activities on Hepatocellular Carcinoma

The benzylideneindolinone 6-chloro-3-(3′-trifluoromethylbenzylidene)-1,3-dihydroindol-2-one (4) was reported to exhibit potent and selective growth inhibitory effects on hepatocellular carcinoma (HCC). Corroborative evidence supported multi-receptor tyrosine kinase (RTK) inhibition as a possible mode of action. However, the poor physicochemical properties of 4 limited its furtherance as a lead compound. In this study, the modification of 4 was investigated with the aim of improving its potency and physicochemical profile. The 6-fluorobenzylideneindolinone 3-12 bearing a 3′-N-propylaminosulfonyl substituent was found to be a promising substitute. Compound 3-12 [6-fluoro-3-(3′-N-propylaminosulfonylbenzylidene)-1,3-dihydroindol-2-one] was found to be tenfold more soluble than 4 and to have sub-micromolar growth inhibitory activities on HCC cells. It is apoptogenic and inhibits the phosphorylation of several RTKs in HuH7, of which the inhibition of FGFR4 and HER3 are prominent. Compound 3-12 decreased the tumor load in a physiologically relevant orthotopic HCC xenograft murine model. Structure-activity relationships support pivotal roles for the fluoro and N′-propylaminosulfonyl moieties in enhancing cell-based activity and moderating the physicochemical profile (solubility, permeability) of 3-12.

AN AGENT FOR PLASMINOGEN-ACTIVATION AND MATRIX METALLOPROTEINASE ASSOCIATED CONDITIONS AND METHODS OF USE

The present invention provides methods and compounds useful in the treatment of conditions such as metastatic cancer spread and atherosclerosis using oxamflatin and derivatives thereof. It has been found that oxamflatin and derivatives thereof are able to