55791-52-1

Basic information

• Product Name: 2,4-Dimethoxybenzylchloride
• Synonyms: 2,4-Dimethoxybenzylchloride;Benzene, 1-(chloroMethyl)-2,4-diMethoxy-
• CAS NO: 55791-52-1
• Molecular Formula: C₉H₁₁ClO₂
• Molecular Weight: 186.63544
• Mol File: 55791-52-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 268.422 °C at 760 mmHg
• Flash Point: 104.401 °C
• Appearance: /
• Density: 1.13 g/cm³
• Vapor Pressure: 0.013mmHg at 25°C
• Refractive Index: 1.51
• CAS DataBase Reference: 2,4-Dimethoxybenzylchloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dimethoxybenzylchloride(55791-52-1)
• EPA Substance Registry System: 2,4-Dimethoxybenzylchloride(55791-52-1)

Safety Data

• Hazardous Substances Data: 55791-52-1(Hazardous Substances Data)

Usage

General Description

2,4-Dimethoxybenzylchloride is a chemical compound with the molecular formula C9H11ClO2. It is a white crystalline powder and is commonly used as an intermediate in the synthesis of other organic compounds. 2,4-Dimethoxybenzylchloride is often employed in the pharmaceutical industry to produce various drugs and medications. It is also used in organic synthesis for the preparation of fragrances, dyes, and other fine chemicals. This chemical is known to be irritating to the skin, eyes, and respiratory system, and proper handling and safety precautions should be observed when working with it.

InChI:InChI=1/C9H11ClO2/c1-11-8-4-3-7(6-10)9(5-8)12-2/h3-5H,6H2,1-2H3

Upstream product

• 7314-44-5 2,4-dimethoxylbenzyl alcohol 
• 613-45-6 2,4-Dimethoxybenzaldehyde 

Downstream Products

• 158307-79-0 4,5-dihydro-2-<2-(2',4'-dimethoxybenzyl)-3-methoxy-4-methylphenyl>-4,4'-dimethyloxazole 
• 127870-66-0 2-(2',4'-dimethoxybenzyl)-3-methoxy-5-methylbenzoic acid 

Relevant articles and documents

Discovery of Plant Growth Stimulants by C-H Arylation of 2-Azahypoxanthine

A series of new AHX derivatives were synthesized by Pd-catalyzed C-H arylation. Their rice-growth-promoting activity was evaluated in vivo. Among the synthesized compounds, C8 phenyl-substituted AHX showed remarkable growth-promoting activity on rice. The

On the Necessity of Nucleobase Protection for 2-Thiouracil for Fmoc-Based Pseudo-Complementary Peptide Nucleic Acid Oligomer Synthesis

A selection of benzyl-based protecting groups for thiouracil (SU) for the synthesis of pseudo-complementary peptide nucleic acid (PNA) has been evaluated. The 4-methoxybenzyl-protecting group that has found use for SU during Boc-based oligomerization is also suitable for Fmoc-based oligomerization. Furthermore, it is demonstrated that SU protection is unnecessary for the successful synthesis of thiouracil-containing PNA. The new 2-thiothymine (ST) PNA monomer has also been prepared and incorporated into an oligomer and its binding to complementary PNA evaluated.

Phosphine functionalized polyphosphazenes: soluble and re-usable polymeric reagents for highly efficient halogenations under Appel conditions

In this paper we present the preparation and application of a novel soluble phosphine functionalized polyphosphazene (poly[3-(diphenylphosphino)propylamino]phosphazene) and investigate its application as a polymeric reagent. Upon chlorination of the pendant phosphine groups, the polymer was found to facilitate the rapid and efficient transformation of alcohols to the corresponding chlorides and bromides under Appel-type conditions. Reaction times followed by 31P NMR spectroscopy are shown to be rapid (several minutes) and the yields for the transformation of alcohols to the corresponding halides are in the range 80–99?%. The facile recovery of the oxidized polymeric agent by precipitation is also described, offering a significant advantage over notoriously difficult to remove small molecule phosphine oxide by-products. Furthermore the regeneration of the reactive phosphine chloride pendant groups is demonstrated, which could be efficiently re-used in a further chlorination reaction. Graphical abstract: [Figure not available: see fulltext.]