55899-42-8

Basic information

• Product Name: 1,2-Benzenediamine,N-propyl-(9CI)
• Synonyms: 1,2-Benzenediamine,N-propyl-(9CI)
• CAS NO: 55899-42-8
• Molecular Formula: C₉H₁₄N₂
• Molecular Weight: 150.224
• Product Categories: AMINEPRIMARY
• Mol File: 55899-42-8.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 278.4 °C at 760 mmHg
• Flash Point: 141.5 °C
• Appearance: /
• Density: 1.041 g/cm³
• Vapor Pressure: 0.00428mmHg at 25°C
• Refractive Index: 1.6
• CAS DataBase Reference: 1,2-Benzenediamine,N-propyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Benzenediamine,N-propyl-(9CI)(55899-42-8)
• EPA Substance Registry System: 1,2-Benzenediamine,N-propyl-(9CI)(55899-42-8)

Safety Data

• Hazardous Substances Data: 55899-42-8(Hazardous Substances Data)

Usage

General Description

1,2-Benzenediamine, N-propyl-(9CI) is a chemical compound composed of a benzene ring with two amino groups and a propyl group attached to one of the amino groups. It is also known as 1,2-diaminopropane and is a primary aromatic amine. 1,2-Benzenediamine,N-propyl-(9CI) is used in the production of dyes, rubber chemicals, and pharmaceuticals. It is also a common ingredient in hair dyes and other cosmetic products. However, the use of 1,2-Benzenediamine, N-propyl-(9CI) is restricted in many countries due to its potential toxic and carcinogenic effects on humans. Additionally, exposure to this compound may cause skin irritation and allergic reactions in some individuals. Therefore, it is important to handle and use this chemical with caution and adhere to safety guidelines.

InChI:InChI=1/C9H14N2/c1-2-7-11-9-6-4-3-5-8(9)10/h3-6,11H,2,7,10H2,1H3

Upstream product

• 55432-58-1 2-nitro-N-propylbenzenamine 
• 13347-27-8 N-(2-Nitrophenyl)-N-prop-2-enylamine 
• 55899-43-9 N-allyl-1,2-phenylenediamine 
• 7765-40-4 n-propyl-2,1,3-benzothiadiazolium 2,4-dinitrobenzenesulphonate 
• 540-54-5 1-Chloropropane 
• 15223-25-3 N,N-dibenzylidenebenzene-1,2-diamine 
• 88-73-3 2-Chloronitrobenzene 
• 106-94-5 propyl bromide 
• 95-54-5 1,2-diamino-benzene 
• 1493-27-2 ortho-nitrofluorobenzene 
• 55432-23-0 cyclopropyl-(2-nitro-phenyl)-amine 

Downstream Products

• 58785-14-1 2-[(2-Propylamino-phenylamino)-methylene]-malonic acid diethyl ester 
• 81327-51-7 C₃₆H₄₄N₈P₄ 
• 124-40-3 dimethyl amine 
• 58785-19-6 2-({2-[Propyl-(toluene-4-sulfonyl)-amino]-phenylamino}-methylene)-malonic acid diethyl ester 
• 1072930-35-8 2-(4-bromo-3-chloro-phenyl)-1-propyl-1H-benzoimidazole 
• 1072930-70-1 (4-chloro-phenyl)-[5-(1-propyl-1H-benzoimidazol-2-yl)-thiazol-2-yl]-amine 
• 1072930-14-3 6-(1-propyl-1H-benzoimidazol-2-yl)-pyridazin-3-ol 
• 1072930-13-2 (4-chloro-phenyl)-[6-(1-propyl-1H-benzoimidazol-2-yl)-pyridazin-3-yl]-amine 
• 1072929-03-3 3-chloro-N-(4-chlorophenyl)-5-(1-propyl-1H-benzo[d]imidazol-2-yl)pyridin-2-amine 
• 65202-75-7 2-benzyl-1-propyl-1H-benzo[d]imidazole 
• 314769-68-1 2-phenyl-1-n-propyl-1H-benzo[d]imidazole 
• 1072930-34-7 [2-chloro-4-(1-propyl-1H-benzoimidazol-2-yl)-phenyl]-(6-methyl-pyridin-3-yl)-amine 

Relevant articles and documents

2-aminobenzimidazoles for leishmaniasis: From initial hit discovery to in vivo profiling

Leishmaniasis is a major infectious disease with hundreds of thousands of new cases and over 20,000 deaths each year. The current drugs to treat this life-threatening infection have several drawbacks such as toxicity and long treatment regimens. A library of 1.8 million compounds, from which the hits reported here are publicly available, was screened against Leishmania infantum as part of an optimization program; a compound was found with a 2-aminobenzimidazole functionality presenting moderate potency, low metabolic stability and high lipophilicity. Several rounds of synthesis were performed to incorporate chemical groups capable of reducing lipophilicity and clearance, leading to the identification of compounds that are active against different parasite strains and have improved in vitro proper-ties. As a result of this optimization program, a group of compounds was further tested in anticipation of in vivo evaluation. In vivo tests were carried out with compounds 29 (L. infantum IC50: 4.1 μM) and 39 (L. infantum IC50: 0.5 μM) in an acute L. infantum VL mouse model, which showed problems of poor exposure and lack of efficacy, despite the good in vitro potency.

Structure-activity relationship studies of antiplasmodial cyclometallated ruthenium(II), rhodium(III) and iridium(III) complexes of 2-phenylbenzimidazoles

Benzimidazoles, such as albendazole, thiabendazole and omeprazole have antiplasmodial activity against Plasmodium falciparum and are widely used as scaffolds for metal-based drug research. Incorporating substituents with various lipophilic and electronic

Novel benzimidazolyl tetrahydroprotoberberines: Design, synthesis, antimicrobial evaluation and multi-targeting exploration

A series of novel benzimidazolyl tetrahydroprotoberberines were conveniently designed and efficiently synthesized from berberine via direct cyclization of tetrahydroprotoberberine aldehyde and o-phenylene diamines under metal-free aerobic oxidation. All the new compounds were characterized by IR, 1H NMR, 13C NMR and HRMS spectra. The antimicrobial evaluation revealed that the 5-fluorobenzimidazolyl derivative 5b was the most active antibacterial and antifungal molecule with broad spectrum in comparison to Berberine, Chloromycin, Norfloxacin and Fluconazole. It triggered almost no resistance development against MRSA even after 15 passages. Further studies demonstrated that compound 5b could not only effectively interact with Topo IA by hydrogen bonds, but also intercalate into calf thymus DNA and cleave pBR322 DNA, which might be responsible for its powerful bioactivities.