560101-02-2

Basic information

• Product Name: Carbamic acid, [2-[[hydroxy(4-hydroxyphenyl)acetyl]methylamino]ethyl]methyl-, 1,1-dimethylethyl ester
• CAS NO: 560101-02-2
• Molecular Formula: C17H26N2O5
• Molecular Weight: 338.404
• Mol File: 560101-02-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [2-[[hydroxy(4-hydroxyphenyl)acetyl]methylamino]ethyl]methyl-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [2-[[hydroxy(4-hydroxyphenyl)acetyl]methylamino]ethyl]methyl-, 1,1-dimethylethyl ester(560101-02-2)
• EPA Substance Registry System: Carbamic acid, [2-[[hydroxy(4-hydroxyphenyl)acetyl]methylamino]ethyl]methyl-, 1,1-dimethylethyl ester(560101-02-2)

Safety Data

• Hazardous Substances Data: 560101-02-2(Hazardous Substances Data)

Upstream product

• 1198-84-1 4-hydroxymandelic acid 
• 177587-81-4 bis(1,1-dimethylethyl) [1,2-ethylenediamine]-1,1'-dicarboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 112257-19-9 tert-butyl N-methyl-N-<2-(methylamino)ethyl>carbamate 

Downstream Products

• 560101-04-4 carbonic acid 4-({[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-methyl-carbamoyl}-hydroxy-methyl)-phenyl ester 4-nitro-phenyl ester 

Relevant articles and documents

Photo-triggerable hydrogel-nanoparticle hybrid scaffolds for remotely controlled drug delivery

Remotely-triggerable drug delivery systems enable the user to adjust dosing regimens on-demand based on a patient's physiological response and clinical needs. However, currently reported systems are limited by the non-specific leakage of drugs in the absence of triggering and the lack of repeatability over multiple cycles of release. To this end, we have designed a unique hydrogel-nanoparticle hybrid scaffold that provides a chemically-defined, remotely-triggerable and on-demand release of small molecule drugs. Our hybrid platform consists of three distinct components: (1) a photo-triggerable chemical compound, which serves to release a covalently-bound drug upon photo-irradiation, (2) a nanoparticle, which serves to covalently bind the photo-triggerable compound, and (3) a polymeric hydrogel, which serves to hold the drug-conjugated nanoparticle. Upon photo-irradiation, the activation of the photo-triggerable compound is designed to initiate a series of intramolecular chemical rearrangements, which would cleave the covalently-bound drug and release it from the hydrogel. The combination of these distinct components in a single scaffold proved to be an effective drug delivery system, as demonstrated by the delivery of a model drug to a malignant cancer line. Our hybrid scaffold can be easily tuned for practically any biological application of interest, thus offering immense potential for clinical therapies.