1198-84-1Relevant articles and documents
Synthesis of racemic mandelic acids with the composite phase transfer catalyst β-cyclodextrin-[bmim]PF6
Yang, Ben-Yong,Yang, De-Hong
, p. 484 - 485 (2011)
Ionic liquids were employed as a part of composite phase transfer catalyst to synthesise mandelic acid, and it is found that [bmim]PF6 coupled with β-cyclodextrin is the most effective catalyst, which was also applicable to other reactions used to synthesise mandelic acid derivatives. Reaction conditions were optimized and the products were characterised by 1H NMR and IR.
Metal ion catalysis in the hydroxyalkylation of phenol with glyoxylic acid
Hoefnagel, A. J.,Peters, J. A.,Bekkum, H. van
, p. 242 - 247 (1988)
The hydroxyalkylation reaction of phenol with glyoxylic acid in aqueous medium is found to be homogeneously catalyzed by various metal ions.Catalysis with MII ions results in a reaction product with an ortho/para ratio of 0.2 to 1.1, whereas catalysis using higher valent cations, because of their ability to form mixed complexes with phenol and glyoxylic acid, affords a reaction product with an ortho/para ratio 1.3 to 28.The catalyzed Cannizzaro reaction of glyoxylic acid was observed as a side-reaction.Addition of a suitable inert ligand, e. g. oxalic acid or NTA, is shown to decrease the ortho/para ratio and suppress the Cannizzaro reaction.The coordination of glyoxylic acid and its hydrate with several cations has been studied by NMR techniques and a mechanism of the catalyzed hydroxyalkylation and Cannizzaro reaction is proposed.
Butenolide derivative as well as preparation method and application thereof
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Paragraph 0045-0048, (2020/07/21)
The invention discloses a butenolide compound as well as a preparation method and an application thereof. The butenolide derivative has the inhibitory activity of protein tyrosine phosphatase 1B (PTP1B), improves insulin resistance of HepG2 cells, generates a remarkable hypoglycemic effect and can be used for preparing a medicine for treating diabetes mellitus.
Activity-based fluorescent probes that target phosphatases
Zhu, Qing,Huang, Xuan,Chen, Grace Y. J.,Yao, Shao Q.
, p. 2669 - 2672 (2007/10/03)
We have successfully designed and synthesized two fluorescently-labeled, activity-based probes, Probe 1 and Probe 2, which were shown to label protein tyrosine phosphatases specifically, as well as other types of phosphatases. The probes were not reactive towards the other non-phosphatase enzymes tested. These probes may find potential applications in large-scale proteomic experiments whereby subclasses of proteins may be selectively identified.