68758-69-0Relevant articles and documents
Butenolide derivative as well as preparation method and application thereof
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Paragraph 0045-0047; 0049, (2020/07/21)
The invention discloses a butenolide compound as well as a preparation method and an application thereof. The butenolide derivative has the inhibitory activity of protein tyrosine phosphatase 1B (PTP1B), improves insulin resistance of HepG2 cells, generates a remarkable hypoglycemic effect and can be used for preparing a medicine for treating diabetes mellitus.
One-pot, diversity-oriented synthesis of aryl-substituted benzoxacycles including benzofuran, coumarin, and benzoxazepine
Masui, Hisashi,Ohkawa, Eri,Kitahara, Rika,Wanibuchi, Kiyofumi,Takahashi, Takashi
, p. 2273 - 2290 (2017/12/12)
A one-pot method for the synthesis of benzoxacycles including benzofuran, coumarin, benzoxazepine, and benzoxazocine from a common synthetic intermediate was established. Benzoxacycles are privileged structures in medicinal chemistry and have featured in several clinically used drugs. The synthesis of a benzofuran containing an aryl substituent was accomplished using potassium carbonate and sodium hydride. The one-pot synthesis of coumarin was also carried out using trans-decalin as the solvent. The optimized conditions for the one-pot synthesis of benzoxazepine can also be applied to the synthesis of benzoxazocine.
MANDELIC ACID DERIVATIVES AND PREPARATION THEREOF
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Page/Page column 14, (2008/12/05)
The invention relates to compounds, compositions, methods of using and processes for producing optically active α-hydroxy derivatives using a combination of a chemical and biochemical methods. The process comprises reacting an ester compound with a racemic compound in the presence of an enzyme to obtain compounds (compositions and methods). The compounds produced may be useful for starting materials for physiologically active materials, functional materials and the like.