56374-25-5

Basic information

• Product Name: Ethanone, 2-chloro-1-[4-(2-methylpropyl)phenyl]-
• Synonyms: p-isobutyl phenacyl chloride
• CAS NO: 56374-25-5
• Molecular Formula: C12H15ClO
• Molecular Weight: 210.704
• Mol File: 56374-25-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-chloro-1-[4-(2-methylpropyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-chloro-1-[4-(2-methylpropyl)phenyl]-(56374-25-5)
• EPA Substance Registry System: Ethanone, 2-chloro-1-[4-(2-methylpropyl)phenyl]-(56374-25-5)

Safety Data

• Hazardous Substances Data: 56374-25-5(Hazardous Substances Data)

Upstream product

• 538-93-2 1-phenyl-2-methylpropane 
• 79-04-9 chloroacetyl chloride 
• 104483-03-6 2-(4-isobutyl-phenyl)-2-hydroxy-acetic acid 

Downstream Products

• 351982-44-0 2-amino-4-[(4-isobutyl)phenyl]thiazole 
• 1134177-97-1 4-[(4-iso-butyl)phenyl]-2-(N-benzylamino)thiazole 
• 545384-33-6 4-[(4-iso-butyl)phenyl]-2-(N-acetylamino)thiazole 
• 1134178-09-8 4-[(4-iso-butyl)phenyl]-2-[N-(2-(4-methoxyphenyl)ethyl)amino]thiazole 
• 1134178-03-2 4-[(4-iso-butyl)phenyl]-2-[N-(2-phenylethyl)amino]thiazole 
• 413615-36-8 4-[(4-iso-butyl)phenyl]-2-(N-methylamino)thiazole 
• 38861-78-8 1-(4-isobutyl-phenyl)-ethanone 
• 1553-60-2 ibufenac 
• 219745-15-0 3-(4-Isobutyl-phenyl)-3-oxo-propionic acid methyl ester 

Relevant articles and documents

Bismuth chloride mediated synthesis, antimicrobial, and anti-inflammatory activities of new 4-aryl-2-amino thiazoles

Synthesis of 4-aryl-2-Amino thiazoles (3a-u), (4a-c), and (5a-c) was achieved from the reaction of 4-butyl phenacyl chlorides (2a-c) with N-substituted thioureas, in the presence of Bismuth Chloride. The antimicrobial and anti-inflammatory activities of the final products were also studied. Copyright Taylor & Francis Group, LLC.

Process for preparing α-hydroxy-acids and compounds obtained by this process

The invention relates to a process for preparing α-hydroxy-acids of general formula: STR1 in which R represents hydrogen or a lower alkyl radical and Cy represents a phenyl, naphthyl or heterocyclic radical, these latter three radicals optionally comprising one or more substituents selected from the group consisting of lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy radicals and halogen atoms, process which comprises the treatment of an α-monohalogenated ketone of general formula: STR2 in which R and Cy have the same meaning as above and X represents chlorine, bromine or iodine, in the presence of an aqueous solution of an alkali metal hydroxide, a non-polar organic solvent selected from an aromatic or alicyclic hydrocarbon and oxygen in excess optionally in the presence of an inert gas, the treatment being carried out at a temperature ranging from the boiling temperature of the reaction medium at atmospheric pressure and 240° C. under pressure and the alkali metal so formed is then acidified to obtain the desired acid.