565458-30-2Relevant articles and documents
Optimized synthesis of L-m-tyrosine suitable for chemical scale-up
Humphrey, Cara E.,Furegati, Markus,Laumen, Kurt,Vecchia, Luigi La,Leuten, Thomas,Constanze D Mueller-Hartwieg,Voegtle, Markus
, p. 1069 - 1075 (2012/12/30)
This paper demonstrates how L-m-tyrosine 1 can be synthesized on larger-scale via enzyme-catalyzed kinetic resolution of N-acyl m-tyrosine methyl ester 4. N-Acyl m-tyrosme methyl ester 4 was prepared by a modification of Erlenmeyer's azalactone synthesis followed by hydrogenation of the resultant dehydroamino acid 12. The optimized four-step synthesis utilizes cheap and readily available starting materials and circumvents difficult purification protocols.