60521-86-0

Basic information

• Product Name: L-Phenylalanine, N-acetyl-3-hydroxy-, methyl ester
• CAS NO: 60521-86-0
• Molecular Formula: C12H15NO4
• Molecular Weight: 237.255
• Mol File: 60521-86-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: L-Phenylalanine, N-acetyl-3-hydroxy-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Phenylalanine, N-acetyl-3-hydroxy-, methyl ester(60521-86-0)
• EPA Substance Registry System: L-Phenylalanine, N-acetyl-3-hydroxy-, methyl ester(60521-86-0)

Safety Data

• Hazardous Substances Data: 60521-86-0(Hazardous Substances Data)

Upstream product

• 3618-96-0 (S)-N-acetylphenylalanine 
• 63-91-2 L-phenylalanine 
• 60521-82-6 2-acetylamino-3-(3-hydroxyphenyl)propionic acid methyl ester 
• 565458-30-2 2-(3-hydroxybenzyl)malonic acid dimethyl ester 
• 100-83-4 meta-hydroxybenzaldehyde 

Relevant articles and documents

Oxidative functionalization of aliphatic and aromatic amino acid derivatives with H2O2 catalyzed by a nonheme imine based iron complex

The oxidation of a series of N-acetyl amino acid methyl esters with H2O2 catalyzed by a very simple iminopyridine iron(ii) complex 1 easily obtainable in situ by self-assembly of 2-picolylaldehyde, 2-picolylamine, and Fe(OTf)2 was investigated. Oxidation of protected aliphatic amino acids occurs at the α-C-H bond exclusively (N-AcAlaOMe) or in competition with the side-chain functionalization (N-AcValOMe and N-AcLeuOMe). N-AcProOMe is smoothly and cleanly oxidized with high regioselectivity affording exclusively C-5 oxidation products. Remarkably, complex 1 is also able to catalyze the oxidation of the aromatic N-AcPheOMe. A marked preference for the aromatic ring hydroxylation over Cα-H and benzylic C-H oxidation was observed, leading to the clean formation of tyrosine and its phenolic isomers.