566938-58-7

Basic information

• Product Name: Benzene, 1-(3-iodopropyl)-3-(trifluoromethyl)-
• CAS NO: 566938-58-7
• Molecular Formula: C10H10F3I
• Molecular Weight: 314.089
• Mol File: 566938-58-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(3-iodopropyl)-3-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(3-iodopropyl)-3-(trifluoromethyl)-(566938-58-7)
• EPA Substance Registry System: Benzene, 1-(3-iodopropyl)-3-(trifluoromethyl)-(566938-58-7)

Safety Data

• Hazardous Substances Data: 566938-58-7(Hazardous Substances Data)

Upstream product

• 454-89-7 3-Trifluoromethylbenzaldehyde 
• 78573-45-2 3-[3-(trifluoromethyl)phenyl]propan-1-ol 
• 145485-43-4 4-(3-(trifluoromethyl)phenyl)butanoic acid 
• 1423-26-3 (meta-(trifluoromethyl)phenyl)boronic acid 
• 402-24-4 3-(trifluoromethyl)styrene 

Downstream Products

• 1410044-63-1 2-methylpropane-2-sulfinic acid (1-naphthalen-1-ylethyl)-[3-(3-trifluoromethylphenyl)propyl]amide 
• 364782-34-3 cinacalcet hydrochloride 
• 694495-47-1 (S)-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine 
• 226256-56-0 cinacalcet 

Relevant articles and documents

Nickel(0)-catalyzed linear-selective hydroarylation of unactivated alkenes and styrenes with aryl boronic acids

Herein, we describe the first linear-selective hydroarylation reaction of unactivated alkenes and styrenes with aryl boronic acids, which was achieved by introducing a directing group on the alkenes. This efficient, scalable reaction serves as a method for modular assembly of structurally diverse alkyl arenes, including γ-aryl butyric acid derivatives, which are widely utilized as chemical building blocks for the synthesis of various drugs and other biologically active compounds.

A method for one-step synthesis of carboxylic acids with two extended carbon chains from olefins

The invention relates to a method for one-step synthesis of carboxylic acid with two extended carbon chains from olefin, which comprises the following steps: under the protection of inert gas, sequentially adding an olefin substrate, a photocatalyst, a hydrogen atom transfer reagent, alpha-haloacetic acid, a reducing agent, a solvent and protonic acid into a reactor, and reacting at normal temperature under the irradiation of 25W blue light to obtain a reaction product; diluting, alkalizing, washing, acidifying and extracting the reaction product to obtain an organic phase; and finally, carrying out reduced pressure distillation and column chromatography on the organic phase to obtain a carboxylic acid product with two extended carbon chains; or carrying out reduced pressure distillation and column chromatography on the reaction product to obtain a carboxylic acid product with two extended carbon chains. The invention is simple to operate, direct synthesis conditions are mild, mutual conversion among various functional groups in the traditional carboxylic acid compound synthesis process is avoided, and the atom and step economy of the reaction is improved. Meanwhile, the method disclosed by the invention can also be applied to the simplified synthesis of the medicines cinacarbazide and tirofiban.

Amino-benzimidazole derivatives

Amino-benzimidazole derivatives of the structure STR1are provided which are useful as anti-inflammatory agents. In addition, a method for preparing such compounds, pharmaceutical compositions containing such compounds, and methods for using such pharmaceutical compositions in the treatment of inflammation are taught.