145485-43-4

Basic information

• Product Name: 4-(3-TrifluoroMethyl-phenyl)-butyric acid
• Synonyms: 4-(3-TrifluoroMethyl-phenyl)-butyric acid;Benzenebutanoic acid, 3-(trifluoroMethyl)-;3-(Trifluoromethyl)-benzenebutanoic acid
• CAS NO: 145485-43-4
• Molecular Formula: C₁₁H₁₁F₃O₂
• Molecular Weight: 232.1990496
• EINECS: -0
• Mol File: 145485-43-4.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(3-TrifluoroMethyl-phenyl)-butyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-TrifluoroMethyl-phenyl)-butyric acid(145485-43-4)
• EPA Substance Registry System: 4-(3-TrifluoroMethyl-phenyl)-butyric acid(145485-43-4)

Safety Data

• Hazardous Substances Data: 145485-43-4(Hazardous Substances Data)

Upstream product

• 625-38-7 but-3-enoic acid 
• 1423-26-3 (meta-(trifluoromethyl)phenyl)boronic acid 
• 402-24-4 3-(trifluoromethyl)styrene 
• 79-08-3 bromoacetic acid 
• 454-89-7 3-Trifluoromethylbenzaldehyde 
• 98-17-9 3-Trifluoromethylphenol 
• 191155-77-8 methyl 4-(3-(trifluoromethyl)phenyl)butanoate 

Downstream Products

• 111141-02-7 2,3-dihydro-7-(trifluoromethyl)-4H-1-benzopyran-4-one 
• 885268-02-0 5-(Trifluoromethyl)-3,4-dihydronaphthalen-1(2H)-one 
• 566938-58-7 1-(3-iodopropyl)-3-(trifluoromethyl)benzene 
• 694495-47-1 (S)-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine 
• 54752-50-0 7-trifluoromethyl-1-tetralone 
• 62620-71-7 6-(trifluoromethyl)-3,4-dihydronaphthalen-1(2H)-one 

Relevant articles and documents

Ligand-Controlled Regiodivergence in Nickel-Catalyzed Hydroarylation and Hydroalkenylation of Alkenyl Carboxylic Acids**

A nickel-catalyzed regiodivergent hydroarylation and hydroalkenylation of unactivated alkenyl carboxylic acids is reported, whereby the ligand environment around the metal center dictates the regiochemical outcome. Markovnikov hydrofunctionalization products are obtained under mild ligand-free conditions, with up to 99 % yield and >20:1 selectivity. Alternatively, anti-Markovnikov products can be accessed with a novel 4,4-disubstituted Pyrox ligand in excellent yield and >20:1 selectivity. Both electronic and steric effects on the ligand contribute to the high yield and selectivity. Mechanistic studies suggest a change in the turnover-limiting and selectivity-determining step induced by the optimal ligand. DFT calculations reveal that in the anti-Markovnikov pathway, repulsion between the ligand and the alkyl group is minimized (by virtue of it being 1° versus 2°) in the rate- and regioselectivity-determining transmetalation transition state.

Nickel(0)-catalyzed linear-selective hydroarylation of unactivated alkenes and styrenes with aryl boronic acids

Herein, we describe the first linear-selective hydroarylation reaction of unactivated alkenes and styrenes with aryl boronic acids, which was achieved by introducing a directing group on the alkenes. This efficient, scalable reaction serves as a method for modular assembly of structurally diverse alkyl arenes, including γ-aryl butyric acid derivatives, which are widely utilized as chemical building blocks for the synthesis of various drugs and other biologically active compounds.

Chromanylurea compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor and uses thereof

Compounds that are antagonists of the VR1 receptor, having formula (I) [image] or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein A1, A2, A3, A4, R7, R8, R9, X, Y, Z, L, n, and m, are as defined herein, and are useful in disorders prevented or ameliorated by inhibiting the VR1 receptor.