56820-57-6Relevant articles and documents
Highly Enantioselective Synthesis of Fused Tri- and Tetrasubstituted Aziridines: aza-Darzens Reaction of Cyclic Imines with α-Halogenated Ketones Catalyzed by Bifunctional Phosphonium Salt
Pan, Jianke,Wu, Jia-Hong,Zhang, Hongkui,Ren, Xiaoyu,Tan, Jian-Ping,Zhu, Lixiang,Zhang, Hong-Su,Jiang, Chunhui,Wang, Tianli
supporting information, p. 7425 - 7430 (2019/05/10)
The first enantioselective aza-Darzens reaction of cyclic imines with α-halogenated ketones was realized under mild reaction conditions by using amino-acid-derived bifunctional phosphonium salts as phase-transfer promoters. A variety of structurally dense tri- and tetrasubstituted aziridine derivatives, containing benzofused heterocycles as well as spiro-structures, were readily synthesized in high yields with excellent diastereo- and enantioselectivities (up to >20:1 d.r. and >99.9 % ee). The highly functionalized aziridine products could be easily transformed into different classes of biologically active compounds.
2H-2-benzazepin-1,3-diones
-
, (2008/06/13)
A compound of the formula SPC1 Wherein X and R are as defined hereinafter, at least one of X and R being other than hydrogen, are provided and which are useful as central nervous system stimulants and for inducing increased motor activity as well as in vitro antimicrobial agents.