56858-46-9

Basic information

• Product Name: Ethanone, 2-[(4-methylphenyl)sulfonyl]-1-(4-nitrophenyl)-
• Synonyms: 4-Nitrophenacyl 4'-tolyl sulfone;HMS2791M05
• CAS NO: 56858-46-9
• Molecular Formula: C15H13NO5S
• Molecular Weight: 319.338
• Mol File: 56858-46-9.mol
• Article Data: 27

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-[(4-methylphenyl)sulfonyl]-1-(4-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-[(4-methylphenyl)sulfonyl]-1-(4-nitrophenyl)-(56858-46-9)
• EPA Substance Registry System: Ethanone, 2-[(4-methylphenyl)sulfonyl]-1-(4-nitrophenyl)-(56858-46-9)

Safety Data

• Hazardous Substances Data: 56858-46-9(Hazardous Substances Data)

Upstream product

• 74812-79-6 1-(4-nitrophenyl)-1-trimethylsilyloxyethylene 
• 98-59-9 p-toluenesulfonyl chloride 
• 100-13-0 4-nitrostyrene 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 100-19-6 (4-nitrophenyl)ethanone 
• 98-86-2 acetophenone 
• 1830-68-8 1-isopropenyl-4-nitro-benzene 
• 98-83-9 isopropenylbenzene 
• 19523-28-5 1-methyl-4-(2-phenyl-2-prop-2-ene-1-sulfonyl)-benzene 
• 657-84-1 sodium tosylate 
• 99-81-0 4-Nitrophenacyl bromide 
• 536-57-2 p-toluene sulfinic acid 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 296788-00-6 1-(4-nitrophenyl)ethanone O-acetyl oxime 

Downstream Products

• 1104732-52-6 5-(4-nitrophenyl)-2-phenyl-4-tosyl-2,3-dihydrofuran 
• 1104732-56-0 5-(4-nitrophenyl)-2,2-diphenyl-4-tosyl-2,3-dihydrofuran 
• 61820-99-3 2-diazo-1-(4-nitrophenyl)-2-(toluene-4-sulfonyl)ethanone 

Relevant articles and documents

Reactions of nitrosalicylic aldehydes with chloromethyl tolyl sulfone anion. Synthesis of 2-hydroxydihydrobenzofurans

Vicarious nucleophilic substitution of hydrogen (VNS) with chloromethyl tolyl sulfone carbanion does not occur in 3-, 4- and 5-nitrosalicylaldehydes. Instead, nucleophilic addition to the carbonyl group takes place leading to 2-hydroxydihydrobenzofurans.

Method for synthesizing beta-ketosulfone derivative under mild condition and obtained beta-ketosulfone derivative

The invention discloses a method for synthesizing a beta-ketosulfone derivative under a mild condition, which comprises the following steps: dissolving aryl olefin and sodium sulfinate in a solvent in a reaction container, adding an acidic additive, sealing the reaction container under the conditions that air exists in the reaction container and no transition metal exists, and purifying after reaction to obtain the beta-ketosulfone derivative. The free radical addition oxidation reaction of olefin and sulfinic acid can be realized under the mild condition without transition metal, the reaction raw materials are cheap and easy to obtain, no organic metal reagent or transition metal is needed, air is used as an oxidizing agent, no dangerous peroxide or persulfide is needed, and the method is compatible with air. The method has the advantages of simple operation and the like, and overcomes the defects of transition metal participation, large catalyst consumption, expensive reagents, high method cost, more reaction steps, more by-products and the like in the prior art.

Photosensitizer-free synthesis of β-keto sulfones: Via visible-light-induced oxysulfonylation of alkenes with sulfonic acids

A practical and environment-friendly methodology for the construction of β-keto sulfones through visible-light induced direct oxysulfonylation of alkenes with sulfonic acids at ambient temperature under open-air conditions was developed. Most importantly, the reaction proceeded smoothly without the addition of any photocatalyst or strong oxidant, ultimately minimizing the production of chemical waste.