57179-07-4

Basic information

• Product Name: Quinoline, 6,7-dimethoxy-2-phenyl-
• CAS NO: 57179-07-4
• Molecular Formula: C17H15NO2
• Molecular Weight: 265.312
• Mol File: 57179-07-4.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Quinoline, 6,7-dimethoxy-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinoline, 6,7-dimethoxy-2-phenyl-(57179-07-4)
• EPA Substance Registry System: Quinoline, 6,7-dimethoxy-2-phenyl-(57179-07-4)

Safety Data

• Hazardous Substances Data: 57179-07-4(Hazardous Substances Data)

Upstream product

• 1016-58-6 6-nitroveratryl alcohol 
• 98-85-1 1-Phenylethanol 
• 188174-23-4 (2-amino-4,5-dimethoxyphenyl)methanol 
• 536-74-3 phenylacetylene 
• 148495-00-5 5,6-dimethoxy-2,1-benzoisoxazole 
• 19433-17-1 acetophenone O-acetyloxime 
• 1636-34-6 2,3-diphenyl-2,3-butanediol 
• 20357-25-9 6-nitroveratraldehyde 
• 98-86-2 acetophenone 
• 105-57-7 diethyl acetal 
• 100-52-7 benzaldehyde 
• 6315-89-5 3,4-dimethoxyaniline 
• 63190-11-4 (3,4-dimethoxy-6-nitro-benzyliden)-aniline 
• 113138-14-0 4,5-Dimethoxy-2-vinyl-phenylamine 

Downstream Products

• 855764-75-9 2-phenyl-quinoline-6,7-diol 

Relevant articles and documents

Synthesis of Quinolines via Iron-Catalyzed Redox Condensation of Alcohols with 2-Nitrobenzyl Methyl Ether/2-Nitrobenzyl Alcohols

An iron-catalyzed redox condensation of 2-nitrobenzyl alcohols, formic acid, and alcohols has been developed, which affords substituted quinolines with carbon dioxide and water as the only side products. With the use of formic acid as a redox moderator to fill the electron gap of the global redox condensation process, the reaction goes smoothly with a smaller amount of alcohol in comparison to previous reports (i.e. 1.2 equiv versus 3.3-4 equiv). The reaction goes equally well when 2-nitrobenzyl methyl ether was used instead of 2-nitrobenzyl alcohol under otherwise identical conditions, shedding a new light on the study of this quinoline synthetic method.

Quinoline derivative as well as preparation method and application thereof

The invention belongs to the technical field of chemical drug synthesis, and particularly relates to a quinoline derivative as well as a preparation method and application thereof. In a reaction system, firstly, a metal catalyst, a ligand and a silicon hydrogen reagent interact to generate metal hydride, the metal hydride and an alkyne compound are subjected to addition, the metal hydride and an anthranil compound are subjected to an electrophilic amination reaction, and then the polysubstituted quinoline derivative is obtained through intramolecular cyclization. According to the invention, the starting raw materials such as the alkyne and the anthranil compound of the reaction are cheap and easily available, a variety of different polysubstituted quinoline derivatives can be constructed by using the one-step method, and can be rapidly converted into other compounds through the oxidation, the reduction, the coupling and other approaches of the target molecule so as to provide the good application prospect in the fields of drug development and material preparation; and the method is mild in condition, green, efficient, simple to operate and very suitable for large-scale industrial production.

Molybdenum-Catalyzed Sustainable Friedl?nder Synthesis of Quinolines

Polysubstituted quinolines have been efficiently synthesized from nitroarenes and glycols, as reducing agents, under dioxomolybdenum(VI)-catalysis. Interestingly, the waste reduction byproduct is incorporated into the final heterocycle. This method repres