57189-90-9

Basic information

• Product Name: (4-AMino-phenyl)-cyclopropylMethanone
• Synonyms: (4-AMino-phenyl)-cyclopropylMethanone;4-cyclopropanecarbonylaniline;Methanone, (4-aMinophenyl)cyclopropyl-
• CAS NO: 57189-90-9
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.20044
• Mol File: 57189-90-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 341.2±15.0 °C(Predicted)
• Appearance: /
• Density: 1.216±0.06 g/cm3(Predicted)
• PKA: 2.21±0.10(Predicted)
• CAS DataBase Reference: (4-AMino-phenyl)-cyclopropylMethanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-AMino-phenyl)-cyclopropylMethanone(57189-90-9)
• EPA Substance Registry System: (4-AMino-phenyl)-cyclopropylMethanone(57189-90-9)

Safety Data

• Hazardous Substances Data: 57189-90-9(Hazardous Substances Data)

Usage

General Description

(4-Amino-phenyl)-cyclopropylmethanone is a chemical compound with the molecular formula C10H11NO. It is a cyclopropylketone derivative with a phenyl and amino group attached to the cyclopropyl ring. (4-AMino-phenyl)-cyclopropylMethanone has potential use in pharmaceutical and medicinal chemistry due to its cyclopropyl and ketone functional groups, which play a crucial role in drug discovery and development. Its unique structure and reactivity make it a valuable molecule for designing novel drugs and studying biological systems. Understanding its properties and reactivity can provide insights into the development of new pharmaceuticals with improved efficacy and safety profiles.

Upstream product

• 772-31-6 cyclopropyl(4-fluorophenyl)methanone 
• 540-37-4 p-aminoiodobenzene 
• 4023-34-1 cyclopropanecarboxylic acid chloride 
• 6952-89-2 (4-bromophenyl)(cyclopropyl)methanone 
• 108-86-1 bromobenzene 
• 3481-02-5 cyclopropyl phenyl ketone 
• 103-84-4 Acetanilid 
• 56924-11-9 1-(4-acetylaminophenyl)-4-chloro-1-butanone 
• 93639-12-4 cyclopropyl(4-nitrophenyl)methanone 

Downstream Products

• 93639-12-4 cyclopropyl(4-nitrophenyl)methanone 
• 166337-20-8 {4-[Cyclopropyl-(4-hydroxy-2-oxo-5,6,7,8,9,10-hexahydro-2H-cycloocta[b]pyran-3-yl)-methyl]-phenyl}-carbamic acid benzyl ester 
• 166337-21-9 3-[(4-Aminophenyl)cyclopropylmethyl]-5,6,7,8,9,10-hexahydro-4-hydroxy-2H-cycloocta[b]pyran-2-one 
• 166337-95-7 [4-(Cyclopropyl-hydroxy-methyl)-phenyl]-carbamic acid benzyl ester 
• 93639-13-5 4-chloro-4'-nitrobutyrophenone 
• 85562-17-0 8-<4-(4-nitrophenyl)-4-oxobutyl>-1-phenyl-1,3,8-triazaspiro<4.5>decan-4-one 
• 150717-69-4 4-(4-chlorophenyl)-1-<4-(4-nitrophenyl)-4-oxobutyl>-4-piperidinol 
• 749-02-0 spiperone 
• 52-86-8 haloperidol 
• 166337-94-6 (4-Cyclopropanecarbonyl-phenyl)-carbamic acid benzyl ester 

Relevant articles and documents

Silver-catalyzed intermolecular amination of fluoroarenes

A novel highly selective Ag-catalyzed intermolecular amination of fluoroarenes has been developed. This transformation starts from readily available 4-carbonyl fluorobenzene and NaN3 or other nitrogen-source, via amination followed by C-F bond cleavage, thus affording the desired 4-carbonyl arylamine products under mild conditions. The reaction is accelerated using a small amount of water. This pathway is distinct from a previously reported radical amination reaction.

Direct preparation of new organozinc reagents, aminophenylzinc iodides, and their applications

New organozinc reagents, 4-aminophenyl zinc iodide (A) and 3-aminophenyl zinc iodide (B), have been generated easily and effectively by the direct insertion of active zinc to iodoanilines which possess acidic protons. The subsequent coupling reactions of the organozincs with various acid chlorides turned out to be an efficient tool for the preparation of aminophenyl ketones.

Rapid and efficient synthesis of high-purity fluorine-18 labeled haloperidol and spiperone via the nitro precursor in combination with a new HPLC separation method

We have completed a convenient synthesis of fluorine-18 labeled butyrophenone neuroleptics from their nitro precursors. Thus, we have developed an efficient single-columm HPLC system using a C18-bonded vinyl alcohol copolymer gel (octadecyl polymer, ODP) column and strongly alkaline solvent systems for purifying of the 18F-labeled butyrophenone neuroleptics obtained by a single-stp 18F-for-nitro exchange reaction. The method has been applied to the synthesis of two typical butyrophenone neuroleptics ([18F]haloperidol and [18F]spiperone) with high purity in high yield. With information concerning the optimized conditions for the 18F-for-nitro exchange reaction, the synthetic method would be useful for synthesizing various 18F-labeled compounds.