93639-13-5

Basic information

• Product Name: 1-Butanone, 4-chloro-1-(4-nitrophenyl)-
• CAS NO: 93639-13-5
• Molecular Formula: C10H10ClNO3
• Molecular Weight: 227.647
• Mol File: 93639-13-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Butanone, 4-chloro-1-(4-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Butanone, 4-chloro-1-(4-nitrophenyl)-(93639-13-5)
• EPA Substance Registry System: 1-Butanone, 4-chloro-1-(4-nitrophenyl)-(93639-13-5)

Safety Data

• Hazardous Substances Data: 93639-13-5(Hazardous Substances Data)

Upstream product

• 93639-12-4 cyclopropyl(4-nitrophenyl)methanone 
• 103-84-4 Acetanilid 
• 56924-11-9 1-(4-acetylaminophenyl)-4-chloro-1-butanone 
• 57189-90-9 (4-aminophenyl)(cyclopropyl)methanone 

Downstream Products

• 150717-69-4 4-(4-chlorophenyl)-1-<4-(4-nitrophenyl)-4-oxobutyl>-4-piperidinol 
• 749-02-0 spiperone 
• 52-86-8 haloperidol 
• 85562-17-0 8-<4-(4-nitrophenyl)-4-oxobutyl>-1-phenyl-1,3,8-triazaspiro<4.5>decan-4-one 

Relevant articles and documents

Rapid and efficient synthesis of high-purity fluorine-18 labeled haloperidol and spiperone via the nitro precursor in combination with a new HPLC separation method

We have completed a convenient synthesis of fluorine-18 labeled butyrophenone neuroleptics from their nitro precursors. Thus, we have developed an efficient single-columm HPLC system using a C18-bonded vinyl alcohol copolymer gel (octadecyl polymer, ODP) column and strongly alkaline solvent systems for purifying of the 18F-labeled butyrophenone neuroleptics obtained by a single-stp 18F-for-nitro exchange reaction. The method has been applied to the synthesis of two typical butyrophenone neuroleptics ([18F]haloperidol and [18F]spiperone) with high purity in high yield. With information concerning the optimized conditions for the 18F-for-nitro exchange reaction, the synthetic method would be useful for synthesizing various 18F-labeled compounds.