57268-80-1

Basic information

• Product Name: [6R-[6alpha,7beta(R*)]]-7-[(formyloxy)phenylacetamido]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• Synonyms: [6R-[6alpha,7beta(R*)]]-7-[(formyloxy)phenylacetamido]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;(6R,7R)-7α-[[(R)-(Formyloxy)phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;O-formylcefamandole
• CAS NO: 57268-80-1
• Molecular Formula: C₁₉H₁₈N₆O₆S₂
• Molecular Weight: 490.51282
• EINECS: 260-657-6
• Mol File: 57268-80-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.71g/cm³
• CAS DataBase Reference: [6R-[6alpha,7beta(R*)]]-7-[(formyloxy)phenylacetamido]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [6R-[6alpha,7beta(R*)]]-7-[(formyloxy)phenylacetamido]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid(57268-80-1)
• EPA Substance Registry System: [6R-[6alpha,7beta(R*)]]-7-[(formyloxy)phenylacetamido]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid(57268-80-1)

Safety Data

• Hazardous Substances Data: 57268-80-1(Hazardous Substances Data)

Usage

Definition

ChEBI: A cephalosporin compound having (R)-O-formylmandelamido and N-methylthiotetrazole side groups. It is used (as the sodium salt) as a progrug for cefamandole.

Upstream product

• 29169-64-0 D-2-phenyl-2-formyloxyacetyl chloride 
• 81589-17-5 C₁₆H₂₈N₆O₃S₂Si₂ 
• 29169-63-9 (R)-formiloxy(phenyl)acetic acid 
• 20698-91-3 (R)-methyl mandelate 
• 10500-33-1 isobutyric formic anhydride 
• 65338-32-1 cefamandole 
• 2258-42-6 formyl acetic anhydride 
• 24209-38-9 (6R,7R)-7-amino-3-[(1H-1-methyltetrazol-5-yl)thio]methylceph-3-em-4-carboxylic acid 

Downstream Products

• 42540-40-9 cefamandole nafate 

Relevant articles and documents

Method for improving quality of cemandil sodium by using three-dimensional column plate to purify solvent

The present invention discloses a method for improving the quality of cemandil sodium by using a three-dimensional column plate to purify a solvent. The method comprises: solvent purification, alkylation reaction, cefamandole ester synthesis, extraction, cemandil sodium synthesis, and sterile sub-packaging. According to the present invention, during the cemandil sodium preparation process, the reaction system solvent is purified by using the high-throughput efficient three-dimensional mass transfer column tray technology so as to finally improve the quality of the cemandil sodium product and ensure the quality of the cemandil sodium powder-needle preparation for injection. The invention provides the method for improving the quality of the cemandil sodium powder-needle preparation for injection by using the three-dimensional column tray mass transfer technology to purify the organic solvent.

PROCESS FOR THE FORMYLATION OF CEFAMANDOLE

The present invention relates to a process for the preparation of O-formyl cefamandole, an intermediate in the preparation of cefamandole nafate, by formylation of cefamandole.