- Method for improving quality of cemandil sodium by using three-dimensional column plate to purify solvent
-
The present invention discloses a method for improving the quality of cemandil sodium by using a three-dimensional column plate to purify a solvent. The method comprises: solvent purification, alkylation reaction, cefamandole ester synthesis, extraction, cemandil sodium synthesis, and sterile sub-packaging. According to the present invention, during the cemandil sodium preparation process, the reaction system solvent is purified by using the high-throughput efficient three-dimensional mass transfer column tray technology so as to finally improve the quality of the cemandil sodium product and ensure the quality of the cemandil sodium powder-needle preparation for injection. The invention provides the method for improving the quality of the cemandil sodium powder-needle preparation for injection by using the three-dimensional column tray mass transfer technology to purify the organic solvent.
- -
-
Paragraph 0044; 0045; 0051; 0052; 0058; 0059; 0065; 0066
(2017/05/10)
-
- Cefamandole nafate for reducing anaphylaxis and preparation thereof
-
The invention relates to an antibiotic drug, in particular to cefamandole nafate for reducing anaphylaxis. The compound has the advantages of high yield, high purity and the like, and is suitable for industrial production, and product stability and anaphylaxis reducing and clinic application of a preparation are all obviously improved .
- -
-
Paragraph 0023
(2016/12/01)
-
- PROCESS FOR THE PREPARATION OF CEFAMANDOLE NAFATE
-
The present invention relates to a process for the preparation of cefamandole nafate from cefamandole and to the use thereof in the manufacture of a medicament for treatment of a bacterial disease.
- -
-
Page/Page column 9-10
(2013/05/09)
-
- PROCESS FOR THE FORMYLATION OF CEFAMANDOLE
-
The present invention relates to a process for the preparation of O-formyl cefamandole, an intermediate in the preparation of cefamandole nafate, by formylation of cefamandole.
- -
-
Page/Page column 8-9
(2013/05/09)
-