5730-76-7

Basic information

• Product Name: METHYL 4'-AMINO[1,1'-BIPHENYL]-4-CARBOXYLATE
• Synonyms: AKOS BAR-0154;4'-AMINOBIPHENYL-4-CARBOXYLIC ACID METHYL ESTER;METHYL 4'-AMINO[1,1'-BIPHENYL]-4-CARBOXYLATE;SALOR-INT L480193-1EA;Methyl4’-aminobiphenyl-4-carboxylate
• CAS NO: 5730-76-7
• Molecular Formula: C₁₄H₁₃NO₂
• Molecular Weight: 227.26
• Product Categories: Heterocyclic Compounds
• Mol File: 5730-76-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 179-182°C
• Boiling Point: 382.5 °C at 760 mmHg
• Flash Point: 220.2 °C
• Appearance: /
• Density: 1.166 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• PKA: 3.97±0.10(Predicted)
• CAS DataBase Reference: METHYL 4'-AMINO[1,1'-BIPHENYL]-4-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4'-AMINO[1,1'-BIPHENYL]-4-CARBOXYLATE(5730-76-7)
• EPA Substance Registry System: METHYL 4'-AMINO[1,1'-BIPHENYL]-4-CARBOXYLATE(5730-76-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 5730-76-7(Hazardous Substances Data)

Usage

Uses

Methyl 4''-aminobiphenyl-4-carboxylate

Upstream product

• 540-37-4 p-aminoiodobenzene 
• 99768-12-4 4-methoxycarbonylphenylboronic acid 
• 619-44-3 methyl 4-iodobenzoate 
• 214360-73-3 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline 
• 586-78-7 para-nitrophenyl bromide 
• 14047-29-1 4-carboxyphenylboronic acid 
• 92-89-7 4'-nitro-biphenyl-4-carboxylic acid 
• 92-93-3 1-phenyl-4-nitrobenzene 
• 135-69-3 4-acetyl-4'-nitrobiphenyl 
• 5730-75-6 4'-nitro-1,1'-biphenyl-4-carboxylic acid methyl ester 
• 106-40-1 4-bromo-aniline 

Downstream Products

• 1360630-63-2 methyl 4'-(6-methoxynaphthalene-2-sulfonamido)biphenyl-4-carboxylate 
• 1360630-52-9 methyl 4'-(naphthalene-2-sulfonamido)biphenyl-4-carboxylate 
• 1597448-33-3 C₂₀H₁₅NO₃ 
• 1597448-34-4 C₂₆H₂₀N₂O₂ 
• 1597448-32-2 C₂₁H₁₇NO₃ 
• 878010-43-6 4'-(6-tert-butoxycarbonylaminohexanoylamino)-biphenyl-4-carboxylic acid methyl ester 
• 5730-78-9 4-(4-aminophenyl)benzoic acid 

Relevant articles and documents

Selective Carbon-Carbon Bond Amination with Redox-Active Aminating Reagents: A Direct Approach to Anilines?

Amines are among the most fundamental motifs in chemical synthesis, and the introduction of amine building blocks via selective C—C bond cleavage allows the construction of nitrogen compounds from simple hydrocarbons through direct skeleton modification. Herein, we report a novel method for the preparation of anilines from alkylarenes via Schmidt-type rearrangement using redox-active amination reagents, which are easily prepared from hydroxylamine. Primary amines and secondary amines were prepared from corresponding alkylarenes or benzyl alcohols under mild conditions. Good compatibility and valuable applications of the transformation were also displayed.

Aromatic amine compound synthesis method

The invention discloses an aromatic amine compound synthesis method which is characterized in that the method is implemented according to any of two methods. The first method includes the steps: mixing an alkyl aromatic compound with a general formula (I) and a nitrogen-containing compound with a general formula (II); performing reaction on mixture under an oxidizing agent and an organic solvent to obtain an aromatic amine compound with a general formula (III). The second method includes the steps: mixing an aromatic alcohol derivative with a general formula (I') and the nitrogen-containing compound with the general formula (II); performing reaction on mixture under an acid additive and an organic solvent to prepare the aromatic amine compound with the general formula (III). According to the method, a lot of alkyl aromatic compounds or aromatic alcohol derivatives firstly serve as raw materials, and the raw materials are reacted to generate the aromatic amine compound without the action of metal catalysis. Compared with a traditional synthesis method, the synthesis method has the advantages that the method is high in yield and simple in condition, waste discharging amount is less,metal participation is omitted, a reaction device is simple, industrial production is easily achieved and the like. The method has a wide application prospect.

Structure-activity relationship study of E6 as a novel necroptosis inducer

Necroptosis inducers represent a promising potential treatment for drug-resistant cancer. We herein describe the structure modification of E6, which was identified recently as a potent and selective necroptosis inducer. The studies described herein demonstrate for the first time that functionalized biphenyl derivatives possess necroptosis inducer activity. Furthermore, these studies have led to the identification of two promising compounds (5h and 5j) that can be used for further optimization studies as well as mechanism of action investigations.