5763-53-1Relevant articles and documents
GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE
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Paragraph 001498; 001500; 001508; 001509, (2021/01/22)
Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with a defect in glyoxylate metabolism, for example a disease or disorder associated with the enzyme glycolate oxidase (GO) or alterations in oxalate metabolism. Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.
Helianthus-like cucurbit[4]uril and cucurbit[5]uril analogues
Wu, Yufan,Xu, Lixi,Shen, Yenan,Wang, Yang,Wang, Qiaochun
supporting information, p. 6991 - 6994 (2017/08/02)
A new glycoluril-like molecule, cyclopentanopropanediurea (CyP-TD), was prepared by malonic ester synthesis. Its condensation with paraformaldehyde resulted in two Helianthus-like cucurbituril analogues, CyP4TD[4] and CyP5TD[5], with cyclopentano groups evenly distributed on the equators. The structures of the two macrocycles were confirmed by 1H-NMR, HRMS-ES and single-crystal X-ray diffraction. CyP4TD[4] and CyP5TD[5] both exhibit excellent thermal stability, and CyP5TD[5] has better solubility in water and organic solvents, while CyP4TD[4] can hardly dissolve in them.
APOPTOSIS INDUCERS
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Paragraph 00282; 00283, (2014/01/08)
This invention comprises novel compounds which inhibit the activity of anti-apoptotic Bcl-2 family protein members, compositions containing the compounds and methods of treating diseases involving a defect in apoptosis, such as, for example, in the treatment of cancer.