57693-15-9Relevant articles and documents
Discovery of a type III inhibitor of LIM kinase 2 that binds in a DFG-out conformation
Goodwin, Nicole C.,Cianchetta, Giovanni,Burgoon, Hugh A.,Healy, Jason,Mabon, Ross,Strobel, Eric D.,Allen, Jason,Wang, Shuli,Hamman, Brian D.,Rawlins, David B.
supporting information, p. 53 - 57 (2017/01/18)
The first allosteric, type III inhibitor of LIM-kinase 2 (LIMK2) is reported. A series of molecules that feature both an N-phenylsulfonamide and tertiary amide were not only very potent at LIMK2 but also were extremely selective against a panel of other k