577711-94-5

Basic information

• Product Name: ethyl 6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate
• Synonyms: ethyl 6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate;ethyl 6-broMo-1H-pyrrolo[2;1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 6-broMo-, ethyl ester;methyl 6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate
• CAS NO: 577711-94-5
• Molecular Formula: C₁₀H₉BrN₂O₂
• Molecular Weight: 269.09
• Product Categories: CHIRAL CHEMICALS
• Mol File: 577711-94-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.624g/cm³
• Refractive Index: 1.653
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 10.96±0.40(Predicted)
• CAS DataBase Reference: ethyl 6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate(577711-94-5)
• EPA Substance Registry System: ethyl 6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate(577711-94-5)

Safety Data

• Hazardous Substances Data: 577711-94-5(Hazardous Substances Data)

Usage

General Description

Ethyl 6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate is a chemical compound with the molecular formula C11H10BrN2O2. It is a pyrrolopyridine derivative, which is widely utilized in the pharmaceutical industry. ethyl 6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate has various biological activities and is used in the synthesis of potential drug candidates. It exhibits structural features that make it suitable for use in drug design and development. Additionally, it is known for its potential as an antiviral and anticancer agent, making it a valuable compound in medicinal chemistry research. Overall, ethyl 6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate has shown promise for a range of therapeutic applications.

InChI:InChI=1/C10H9BrN2O2/c1-2-15-10(14)7-5-6-3-4-8(11)13-9(6)12-7/h3-5H,2H2,1H3,(H,12,13)

Upstream product

• 577711-92-3 6-Bromo-pyrrolo [2,3-b]pyridine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester 
• 577711-90-1 7-oxy-pyrrolo[2,3-b]pyridine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester 
• 577711-88-7 1-(tert-butyl) 2-ethyl 1H-pyrrolo[2,3-b]pyridine-1,2-dicarboxylate 
• 221675-35-0 1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester 
• 880491-19-0 6-chloro-pyrrolo[2,3-b]pyridine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester 

Downstream Products

• 577712-44-8 6-(benzhydrylidene-amino)-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester 
• 577712-50-6 (4R,9aR)-6-benzyloxy-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester 

Relevant articles and documents

Synthesis and biological evaluation of novel hexahydro-pyrido[3′, 2′:4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT2C receptor agonists

Further lead optimization efforts on previously described 1,2,3,4,10,10a-hexahydro-1H-pyrazino[1,2-a]indoles led to the new class of 5,5a,6,7,8,9-hexahydro-pyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazines culminating in the discovery of (5aR,9R)-2-[(cyclopropylmethoxy)methyl]-5,5a,6, 7,8,9-hexahydro-9-methyl-pyrido[3′, 2′:4,5]pyrrolo[1,2-a]pyrazine 18 as a potent, full 5-HT2C receptor agonist with an outstanding selectivity profile and excellent hERG and phospholipidosis properties.

Piperazine derivatives

The present invention relates to compounds of formula (I) as well as pharmaceutically acceptable salts, solvates and esters thereof. These compounds can be used to prepare pharmaceutical compositions for the treatment or prevention of disorders of the central nervous system, damage to the central nervous system, cardiovascular disorders, gastrointestinal disorders, diabetes, obesity and sleep apnoea.