5780-07-4

Basic information

• Product Name: MYRISTICIN ALDEHYDE
• Synonyms: 5-METHOXYPIPERONAL;3-METHOXY-4,5-METHYLENEDIOXYBENZALDEHYDE;3-METHOXYPIPERONAL;MYRISTICIN ALDEHYDE;1,3-Benzodioxole-5-carboxaldehyde, 7-methoxy-;7-Methoxy-1,3-benzodioxole-5-carbaldehyde;7-methoxy-3-benzodioxole-5-carboxaldehyde;7-methoxy-1,3-benzodioxole-5-carboxaldehyde
• CAS NO: 5780-07-4
• Molecular Formula: C₉H₈O₄
• Molecular Weight: 180.16
• EINECS: 227-304-8
• Product Categories: Aromatic Aldehydes & Derivatives (substituted)
• Mol File: 5780-07-4.mol
• Article Data: 32

Chemical Properties

• Melting Point: 130-132°C
• Boiling Point: 303.2 °C at 760 mmHg
• Flash Point: 134.7 °C
• Appearance: /
• Density: 1.321 g/cm³
• Vapor Pressure: 0.000943mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility: Insoluble in water.
• Sensitive: Air Sensitive
• BRN: 384077
• CAS DataBase Reference: MYRISTICIN ALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: MYRISTICIN ALDEHYDE(5780-07-4)
• EPA Substance Registry System: MYRISTICIN ALDEHYDE(5780-07-4)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• TSCA: Yes
• HazardClass: IRRITANT
• Hazardous Substances Data: 5780-07-4(Hazardous Substances Data)

Usage

Description

Myristicin aldehyde is an organic compound that serves as an important intermediate in the synthesis of various pharmaceuticals and bioactive molecules. It is known for its unique chemical properties and versatile applications across different industries.

Uses

Used in Pharmaceutical Industry:
Myristicin aldehyde is used as a key intermediate in the synthesis of various pharmaceutical compounds for [application reason]. It plays a crucial role in the development of new drugs and therapies.
Used in Synthesis of Antitumor Agents:
Myristicin aldehyde is used as a starting material for the synthesis of oxazole combretastatin A-4 analogs, which exhibit anti-tumor activity. Its involvement in the development of these compounds contributes to the fight against cancer.
Used in Synthesis of Endothelin-A Antagonists:
Myristicin aldehyde is utilized in the synthesis of endothelin-A antagonist ABT-546. This application highlights its importance in the development of treatments for conditions related to endothelin-A receptor activity.
Used in Synthesis of Antidepressants:
Myristicin aldehyde is also employed in the synthesis of the antidepressant rolipram. Its role in the production of this medication underscores its significance in the field of mental health and pharmaceuticals.

InChI:InChI=1/C9H8O4/c1-11-7-2-6(4-10)3-8-9(7)13-5-12-8/h2-4H,5H2,1H3

Upstream product

• 65144-13-0 4-bromo-7-methoxybenzo[d][1,3]dioxole-5-carbaldehyde 
• 20757-83-9 [1,3,5,7,2,6]tetroxadithiocane 2,2,6,6-tetraoxide 
• 3934-87-0 5-hydroxyvanillin 
• 121-33-5 vanillin 
• 74-95-3 1,1-dibromomethane 
• 487-11-6 elemicin 
• 607-91-0 myristicin 
• 487-62-7 isomyristicin 
• 121974-58-1 3-methoxy-4,5-methylenedioxybenzoic acid hydrazide 
• 22934-59-4 (7-methoxybenzo[d][1,3]dioxol-5-yl)methanol 
• 99-24-1 methyl galloate 
• 3934-86-9 methyl 3,4-dihydroxy-5-methoxybenzoate 
• 3934-84-7 3,4-dihydroxy-5-methoxybenzoic acid 
• 22934-58-3 methyl 7-methoxybenzo[d][1,3]dioxole-5-carboxylate 

Downstream Products

• 78173-85-0 trans-2-(α-hydroxy-3,4-dimethoxybenzyl)-3-(3-methoxy-4,5-methylenedioxybenzyl)butyrolactone 
• 82423-79-8 (3S,4R)-4-(6-Bromo-7-methoxy-benzo[1,3]dioxol-5-ylmethyl)-3-[(3,4-dimethoxy-phenyl)-hydroxy-methyl]-dihydro-furan-2-one 
• 1240207-88-8 3-(3-methoxy-4,5-methylenedioxyphenyl)-5-(3-hydroxy-4-methoxyphenyl)-1,2,4-oxadiazole 
• 1221717-33-4 3-(3-hydroxy-4-methoxyphenyl)-5-(3-methoxy-4,5-methylenedioxyphenyl)-1,2,4-triazole 
• 1257321-38-2 C₁₇H₁₆N₂O₇ 
• 1257321-39-3 C₁₉H₂₀N₂O₈ 
• 1221721-82-9 2-(3-hydroxy-4-methoxyphenyl)-5-(3-methoxy-4,5-methylenedioxyphenyl)-1,3,4-oxadiazole 
• 1221717-58-3 2-(3,4,5-trimethoxyphenyl)-5-(3-methoxy-4,5-methylenedioxyphenyl)-1,3,4-oxadiazole 
• 6443-68-1 3-methoxy-4,5-methylenedioxybenzonitrile 
• 526-34-1 5-methoxy-3,4-methylenedioxybenzoic acid 
• 22934-58-3 methyl 7-methoxybenzo[d][1,3]dioxole-5-carboxylate 
• 111394-53-7 3'-hydroxy-3,4-methylenedioxy-4',5-dimethoxy-(E)-stilbene 
• 512184-74-6 3,4'-dimethoxy-4,5-methylenedioxy-3'-O-t-butyldimethylsilylstilbene 
• 512184-75-7 3,4'-dimethoxy-4,5-methylenedioxy-3'-O-t-butyldimethylsilylstilbene 

Relevant articles and documents

-

-

Synthesis and anti-proliferative activities of 5,6,7-trimethoxyflavones and their derivatives

A series of 5,6,7-trimethoxyflavones 1a-1g and their derivatives 2a-2g, 3a-3d, 4 and 5, including the natural products 5,6,7-trimethoxy-4’-hydroxyflavone (1a), 5,6,7,3’,4’ -pentamethoxyflavone (sinensetin, 1 b), 5,6,7-trimethoxy-3’,4’-methyl enedioxy flavone (1c), 5,6,7,3’-tetramethoxy-4,5’-methylenedioxyflavone (1e), 5,6,7, 3’,4’,5’-hextamethoxyflavone (1 g), 5-hydroxy-3,4,2’,3’,4’-pentamethoxy chal-cone (2 b), 5,4’-dihydroxy-6,7-dimethoxy flavone (cirsimaritin, 3a) and 5-hydroxy-6,7,3’, 4’-tetramethoxyflavone (5-demethylsinensetin, 3 b), 3,5,6,7,3’,4’-hexamethoxyflavone (3-methoxysinensetin, 4) and 5’-hydroxy-3,6,7,3’,4’-pentamethoxyflavone (5) were synthesized. Their anti-proliferative activity in?vitro was evaluated against a panel of four human cancer cell lines (Aspc-1, HCT-116, HepG-2 and SUN-5) by the CTG assay. The results showed that most of the synthetic compounds exhibited moderate to high anti-proliferative activities. In particular, compound 3c possess IC50 (5.30 μM) values below 10 μM against Aspc-1 cells and are worthy of further investigation.

An Acid-Catalyzed Epoxide Ring-Opening/Transesterification Cascade Cyclization to Diastereoselective Syntheses of (±)-β-Noscapine and (±)-β-Hydrastine

An acid-catalyzed stereoselective epoxide ring-opening/intramolecular transesterification cascade cyclization reaction and N-Boc deprotection was found to be a successful strategy to construct the phthalide tetrahydroisoquinoline skeleton in one pot. Based on this strategy, the unified and highly diastereoselective routes for the total syntheses of (±)-β-Noscapine and (±)-β-Hydrastine were exploited.