82423-79-8Relevant articles and documents
Structure and Synthesis of the Aryltetralin Lignans Hypophyllanthin and Nirtetralin
Schneiders, Gail E.,Stevenson, Robert
, p. 999 - 1004 (2007/10/02)
Structures previously suggested for hypophyllanthin, the major aryltetralin lignan constituent of Phyllanthus niruri are shown to be incorrect.The structure r-1-(3,4-dimethoxyphenyl)-6-methoxy-t-2,c-3-bismethoxymethyl-7,8-methylenedioxy-1,2,3,4-tetrahydronaphthalene (5) now proposed is confirmed by an unambiguous synthesis.Synthesis of the congener, nirtetralin, is also described.