57801-81-7 Usage
Description
Brotizolam is a potent hypnotic and sedative medication, approximately 60-100 times more potent than flurazepam. It belongs to the class of short-acting, annulated benzodiazepines, which includes triazolam. Brotizolam is characterized by its lack of adverse effects on sleep and performance after arousal, making it a preferred choice for certain applications.
Uses
Used in Pharmaceutical Industry:
Brotizolam is used as a hypnotic and sedative for the treatment of insomnia and other sleep disorders. Its high potency and short-acting nature allow for effective management of sleep issues with minimal side effects on sleep and performance after arousal.
Used in Veterinary Medicine:
In the veterinary field, brotizolam is utilized as an appetite stimulant to encourage food intake in animals that may be experiencing a loss of appetite due to illness or other factors.
Chemical Properties:
Brotizolam is a tan solid, which contributes to its stability and ease of formulation in various dosage forms.
Brand Names:
Some of the brand names under which brotizolam is marketed include Lendorm (Boehringer Ingelheim) and LENDORMIN.
Manufacturing Process
(a) 11.5 g of 7-bromo-5-(o-chlorophenyl)-3H-[2,3e]-thieno-1,4-diazepin-2-
one (see German Patent 2,221,623), were heated at 55° to 60°C with 100 cc
of absolute pyridine and 6.5 g of phosphorus pentasulfide for 4 hours while
stirring. The mixture was allowed to cool and was then poured into 100 cc of
saturated ice-cold NaCl solution. The precipitate was collected by suction
filtration, washed with water, dissolved in 100 cc of methylene chloride, the
solution was dried and evaporated, and the residue was treated with a little
methylene chloride. After suction filtration, 6 g of brown crystalline 7-bromo-
5-(o-chlorophenyl)-3H-[2,3e]-thieno-1,4-diazepine-2-thione, melting point
214°C (decomposition) were obtained.
(b) 6.0 g of this compound were suspended in 100 cc of tetrahydrofuran, and
the suspension was stirred at room temperature with 1.2 g of hydrazine
hydrate for 20 minutes. After evaporation to about 10 cc, 20 cc of ether were
added, and the crystals were collected by suction filtration. Yield: 5.2 g of 7-
bromo-5-(o-chlorophenyl)-2-hydrazino-3H-[2,3e]-thieno-1,4-diazepine,
melting point about 300°C (decomposition).
(c) 5.2 g of this compound were suspended in 50 cc of orthotriethyl acetate,
and the suspension was heated to 80°C. After about 30 minutes a clear
solution was first formed from which later colorless crystals separated out.
The mixture was allowed to cool, and the crystals were collected by suction
filtration and washed with ether. Yield: 5 g of the compound, melting point
211° to 213°C.
Therapeutic Function
Psychotropic
Check Digit Verification of cas no
The CAS Registry Mumber 57801-81-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,8,0 and 1 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 57801-81:
(7*5)+(6*7)+(5*8)+(4*0)+(3*1)+(2*8)+(1*1)=137
137 % 10 = 7
So 57801-81-7 is a valid CAS Registry Number.
InChI:InChI=1/C15H10BrClN4S/c1-8-19-20-13-7-18-14(9-4-2-3-5-11(9)17)10-6-12(16)22-15(10)21(8)13/h2-6H,7H2,1H3
57801-81-7Relevant articles and documents
Process for preparing 6-aryl-4H-S-triazolo[3,4-c]-thieno[2,3-e]-1,4-diazepines
-
, (2008/06/13)
An improved process for preparing 6-aryl-4H-s-triazolo[3,4-c]-thieno[2,3-e]-1,4-diazepines of formula I, wherein: R1 is a hydrogen or halogen atom or a C1-C6 alkyl group, R2 is a hydrogen or halogen atom or a C1-C6 alkyl, C1-C6 hydroxyalkyl, C3-C6 cycloalkyl group or a 5- or 6-membered oxygen-, sulphur- or nitrogen-containing heterocyclic group which may optionally be substituted at the nitrogen atom by a C1-C3 alkyl group, and R3 is a hydrogen or halogen atom,
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