57872-38-5

Basic information

• Product Name: Pyrrolidine, 1-(hydroxyphenylacetyl)-
• CAS NO: 57872-38-5
• Molecular Formula: C12H15NO2
• Molecular Weight: 205.257
• Mol File: 57872-38-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Pyrrolidine, 1-(hydroxyphenylacetyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolidine, 1-(hydroxyphenylacetyl)-(57872-38-5)
• EPA Substance Registry System: Pyrrolidine, 1-(hydroxyphenylacetyl)-(57872-38-5)

Safety Data

• Hazardous Substances Data: 57872-38-5(Hazardous Substances Data)

Upstream product

• 123-75-1 pyrrolidine 
• 4358-87-6 (RS)-methyl mandelate 
• 611-71-2 MANDELIC ACID 
• 1074-12-0 phenylglyoxal hydrate 

Downstream Products

• 103383-80-8 1-phenyl-2-(pyrrolidin-1-yl)ethane-1,2-dione 

Relevant articles and documents

5-endo-dig Cyclization of O-Propargyl Mandelic Acid Amides towards 2,5-Dihydrofurans

5-endo-dig cyclization of O-propargyloxyamides, obtained through a Passerini reaction mediated by boric acid and subsequent propargylation, affords 2,5-dihydrofurans in the presence of tert-butylate. The mechanism of the reaction was studied by using DFT calculations and the results were compared with the behavior of analogous N-propargylamide derivatives.

Synthesis of carboxamides by LDA-catalyzed Haller-Bauer and Cannizzaro reactions

Equation presented. The first direct synthesis of N-alkylcarboxamides and N,N-dialkylcarboxamides by Haller-Bauer (HB) and Cannizzaro-type reactions has been realized. Lithium N,N-diisopropylamide (LDA) catalyst was successfully used in not only the HB reaction of benzylic ketones with lithium N-alkylamides to give the corresponding carboxamides and hydrocarbons but also in the Cannizzaro-type reaction of aldehydes with lithium N-alkylamides or lithium N,N-dialkylamides to give the corresponding carboxamides and alcohols.

Direkte Aminolyse von nicht aktivierten Estern bei hohem Druck

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