4358-87-6Relevant articles and documents
Efficient Synthesis of α-Hydroxy-β-ketoesters from Methyl Phenylglyoxalate and Acid Chlorides mediated by Titanium Trichloride
Araneo, Silvia,Clerici, Angelo,Porta, Ombretta
, p. 2213 - 2216 (1994)
Methyl phenylglyoxalate and acid chlorides undergo rapid condensation reactions on treatment with a TiCl3-THF/CH2Cl2 solution, in the presence of pyridine, at room temperature.
Solvent Effect in the Reduction of α-Keto Esters by Aqueous Titanium Trichloride
Clerici, Angelo,Porta, Ombretta
, p. 5099 - 5104 (1987)
In the reduction of 1 by Ti(III) ion the dimeric 3 or monomeric 4 reduction products could be made to predominate by the choice of the solvent.It is found that (a) dimerization, via coupling of two radicals 2, increases with increasing simultaneously the dielectric constant and the hydrogen ion concentration of the reaction medium and (b) alcohol formation, which occurs via electron transfer between radical species having different redox potentials, increases with decreasing the hydrogen ion concentration of the medium.Under appropriate reaction conditions, the dimerization process is partially stereoselective.Reaction mechanisms are proposed which account for the ratio of both dimer / alcohol and meso / dl under different experimental conditions.
Efficient synthesis of α-aryl serine derivatives via three-component reactions of aryldiazoacetates, anilines and formaldehyde
Wang, Chengjin,Liu, Shunying,Xing, Dong,Wang, Xin,Wu, Xiang,Hu, Wenhao
, p. 11203 - 11208 (2013)
A three-component reaction based on trapping of ammonium ylides with formaldehyde was first reported. This reaction offers a new strategy for the synthesis of α-aryl serine derivatives and can be extended to the preparation of α-aryl threonine derivatives. Synthetic application of the three component reaction for the preparation of hydroquinoxaline derivative was also demonstrated.
Visible Light-Promoted Sulfoxonium Ylides Synthesis from Aryl Diazoacetates and Sulfoxides
Lu, Juan,Li, Lei,He, Xiang-Kui,Xu, Guo-Yong,Xuan, Jun
, p. 1646 - 1650 (2021/05/28)
A visible light-promoted reaction of donor/acceptor diazoalkanes with sulfoxides towards the synthesis of synthetically useful sulfoxonium ylides was reported. The reaction occurred under sole visible light irradiation without the need of any transition-metals or additives, affording the corresponding sulfoxonium ylides in moderate to good yields. The success of late-stage modification of natural isolates or drug candidates, scale-up reaction and transformation of sulfoxonium ylides to other useful molecules further rendered the approach valuable.
KB3H8: An environment-friendly reagent for the selective reduction of aldehydes and ketones to alcohols
Li, Xinying,Mi, Tongge,Guo, Wenjing,Ruan, Zhongrui,Guo, Yu,Ma, Yan-Na,Chen, Xuenian
, p. 12776 - 12779 (2021/12/10)
Selective reduction of aldehydes and ketones to their corresponding alcohols with KB3H8, an air- and moisture-stable, nontoxic, and easy-to-handle reagent, in water and THF has been explored under an air atmosphere for the first time. Control experiments illustrated the good selectivity of KB3H8 over NaBH4 for the reduction of 4-acetylbenzaldehyde and aromatic keto esters. This journal is
Benzophenone compound containing 1,thiadiazole thioether structure and application thereof
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Paragraph 0015-0020, (2021/10/30)
The invention discloses a benzophenone compound containing 1,thiadiazole thioether structure, its characterized in that: its structural formula is as follows: Herein R is an alkyl group. Benzyl or substituted benzyl. The invention is based on the structure of mandelic acid derivatives containing '1,oxadiazole thioether'. The 'hydroxyl group' in the compound structure is replaced by '1,thiadiazole thioether', and a series of benzophenone compounds containing 1,thiadiazole thioether structures has been synthesized, and the compound has good bacteriostatic activity on various plant pathogenic bacteria. Compared with a high-activity compound reported in early-stage work of a title group, the compound has a novel 'ketone' structure, shows certain bacteriostatic activity, and provides an important scientific basis for research and development and creation of new pesticides.
