579-12-4

Basic information

• Product Name: N-methyl-N-(3-methylphenyl)acetamide
• CAS NO: 579-12-4
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.2163
• Mol File: 579-12-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 266.1°C at 760 mmHg
• Flash Point: 114.7°C
• Density: 1.037g/cm³
• Vapor Pressure: 0.00882mmHg at 25°C
• Refractive Index: 1.549
• CAS DataBase Reference: N-methyl-N-(3-methylphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N-(3-methylphenyl)acetamide(579-12-4)
• EPA Substance Registry System: N-methyl-N-(3-methylphenyl)acetamide(579-12-4)

Safety Data

• Hazardous Substances Data: 579-12-4(Hazardous Substances Data)

Upstream product

• 696-44-6 N-methyl-m-toluidine 
• 3847-19-6 2-acetoxypyridine 
• 121-72-2 N,N-dimethyl-m-toluidine 
• 201230-82-2 carbon monoxide 
• 108-44-1 1-amino-3-methylbenzene 
• 108-24-7 acetic anhydride 
• 74-88-4 methyl iodide 
• 537-92-8 3-Methylacetanilide 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 696-44-6 N-methyl-m-toluidine 
• 15258-50-1 N-ethyl-N-methyl-3-methylaniline 
• 1173504-63-6 N-methyl-N-(5-methyl-2-((triisopropylsilyl)ethynyl)phenyl)acetamide 
• 71-50-1 acetate 

Relevant articles and documents

Method for promoting acylation of amine or alcohol by carbon dioxide

The invention relates to a method for promoting acylation of amine or alcohol by carbon dioxide, which comprises the following steps of: mixing an amine compound, carboxylate or thiocarboxylate compound and a reaction solvent under the action of carbon dioxide, and reacting to obtain an amide compound, or under the action of carbon dioxide, mixing the alcohol compound, the thiocarboxylate compound and the reaction solvent [gamma]-valerolactone, and reacting to obtain the ester compound. According to the invention, under the promotion action of carbon dioxide, carboxylate or thiocarboxylate is used as an acylation reagent, and amine and alcohol are converted into amide and ester compounds in the absence of a transition metal catalyst, so that acylation reagents such as acyl chloride or anhydride with irritation and corrosivity are avoided; and the method has the advantages of simple operation, mild reaction conditions, high tolerance of substrate functional groups, strong applicability and high yield, and provides an efficient, reliable and economical preparation method for synthesis of amide and ester compounds.

Carbonylation of C?N Bonds in Tertiary Amines Catalyzed by Low-Valent Iron Catalysts

The first iron catalysts able to promote the formal insertion of CO into the C?N bond of amines are reported. Using low-valent iron complexes, including K2[Fe(CO)4], amides are formed from aromatic and aliphatic amines, in the presence of an iodoalkane promoter. Inorganic Lewis acids, such as AlCl3 and Nd(OTf)3, have a positive influence on the catalytic activity of the iron salts, enabling the carbonylation at a low pressure of CO (6 to 8 bars).

AN ANOMALOUS DEALKYLATION-ACYLATION OF N,N-DIALKYLANILINES

N,N-Dialkylaniline undergoes a thermal N-dealkylation and acylation in the presence of 2-acetoxypyridines.