5829-89-0

Basic information

• Product Name: (+/-)-α-chloro-(2-chlorophenyl)-acetonitrile
• Synonyms: (+/-)-α-chloro-(2-chlorophenyl)-acetonitrile
• CAS NO: 5829-89-0
• Molecular Weight: 186.04
• Mol File: 5829-89-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (+/-)-α-chloro-(2-chlorophenyl)-acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-α-chloro-(2-chlorophenyl)-acetonitrile(5829-89-0)
• EPA Substance Registry System: (+/-)-α-chloro-(2-chlorophenyl)-acetonitrile(5829-89-0)

Safety Data

• Hazardous Substances Data: 5829-89-0(Hazardous Substances Data)

Upstream product

• 2856-63-5 2-Chlorophenylacetonitrile 

Downstream Products

• 444728-11-4 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl)acetonitrile 
• 7041-88-5 N-[2-bromo-5-(2-chloro-phenyl)-thiazol-4-yl]-acetamide 
• 7041-92-1 (2-chloro-phenyl)-thiocyanato-acetonitrile 

Relevant articles and documents

Preparation of Clopidogrel and Its Analogues Methyl Tetrahydrothienopyridine Acetate Compuunds

The present invention disclosed a preparation method of Clopidogrel (X=2-Cl) and its analogues of methyl tetrahydrothienopyridine acetate (I) by using halogen phenyl acetonitrile (VIII) as starting material and tetrahydrothienopyridine acetonitrile (IV), tetrahydrothienopyridine acetate (V) as key intermediates, and further using kinetic resolution to prepare the optical active Clopidogrel and compounds of methyl tetrahydrothenopridine acetate of formula (XII). The Clopidogrel of present invention is a novel high effective and safety drug for inhibition of platelet aggregation. This invention applied systematic technique of racemization of unwanted optical active enantiomer, recover recycle and reuse of resolution agent etc., with greater economic advantages and suitable for commercial scale industrial production. Wherein: X represents atoms of hydrogen, fluorine, chlorine, bromine or iodine, M represents an alkali metal ion.