58481-23-5Relevant articles and documents
Design and synthesis of xanthine analogues as potent and selective PDE5 inhibitors
Wang, Yuguang,Chackalamannil, Samuel,Hu, Zhiyong,Boyle, Craig D.,Lankin, Claire M.,Xia, Yan,Xu, Ruo,Asberom, Theodros,Pissarnitski, Dmitri,Stamford, Andrew W.,Greenlee, William J.,Skell, Jeffrey,Kurowski, Stanley,Vemulapalli, Subbarao,Palamanda, Jairam,Chintala, Madhu,Wu, Ping,Myers, Joyce,Wang, Peng
, p. 3149 - 3152 (2007/10/03)
We have discovered potent and selective xanthine PDE5 inhibitors. Compound 25 (PDE5 IC50=0.6 nM, PDE6/PDE5=101) demonstrated similar functional efficacy and PK profile to Sildenafil (PDE5 IC50=3.5 nM, PDE6/PDE5=7).