58611-62-4Relevant articles and documents
Inhibitors or bone reabsorption and antagonists of vitronectin receptors
-
, (2008/06/13)
Novel inhibitors of bone reabsorption and antagonists of vitronectin receptors The present invention relates to 5-membered ring heterocycles of the formula I, in which E, F, G, W, Y and Z have the meaning given in the patent claims, to their preparation a
Synthesis of D,L-&γ-Hydroxyphosphinothricin, a Potent New Inhibitor of Glutamine Synthetase
Walker, Daniel M.,McDonald, John F.,Logusch, Eugene W.
, p. 1710 - 1711 (2007/10/02)
A flexible synthesis of D,L-γ-hydroxyphosphothricin (GHPPT), a potent inhibitor of the enzyme glutamine synthetase, is described which features silicon-mediated addition of ethyl methylphosphinate to benzyl 2-benzyloxycarbonylamino-4-oxobutyrate; selectiv
Analogues of S adenosylhomocysteine as potential inhibitors of biological transmethylation. Synthesis of analogues with modifications at the 5' thioether linkage
Chang,Coward
, p. 684 - 691 (2007/10/06)
The synthesis of S adenosylhomocysteine analogues, in which the 5' thioether linkage is replaced by an oxygen or nitrogen isostere, has been investigated. These compounds were designed to be resistant to enzyme catalyzed hydrolytic cleavage of the 5' subs