58621-38-8Relevant articles and documents
Synthesis of Polysubstituted 3-Methylisoquinolines through the 6π-Electron Cyclization/Elimination of 1-Azatrienes derived from 1,1-Dimethylhydrazine
Vargas, Didier F.,Larghi, Enrique L.,Kaufman, Teodoro S.
supporting information, p. 5605 - 5614 (2018/10/09)
A convenient one pot microwave-assisted 6π-electron cyclization/aromatization approach toward 3-methylisoquinolines is reported. The starting 1-azatriene derivatives were prepared in situ by reaction of 2-propenylbenzaldehydes with 1,1-dimethylhydrazine, which exhibited superior performance when compared with other hydrazine derivatives. Minor amounts of the related 3,4-dihydro isoquinolines were formed concomitantly with the isoquinolines, and a mechanism for their generation was proposed. The reaction conditions were optimized, and its scope and limitations were explored. In general, the transformation proceeded in moderate to good yields.
A new synthesis of benzofurans from phenols via claisen rearrangement and ring-closing metathesis
Tsai, Tzu-Wei,Wang, Eng-Chi,Li, Sie-Rong,Chen, Yung-Hua,Lin, Yu-Li,Wang, You-Feng,Huang, Keng-Shiang
, p. 1307 - 1318 (2007/10/03)
Based on Claisen rearrangement, the double bond isomerization of O-allyl function together with the formation of O-vinyl function in one pot, and ring-closing metathesis (RCM), various phenols were transformed into various benzofurans in good yields.
