586363-96-4Relevant articles and documents
Nonpeptide RGD antagonists: A novel class of mimetics, the 5,8-disubstituted 1-azabicyclo[5.2.0]nonan-2-one lactam
Bourguet, Erika,Baneres, Jean-Louis,Parello, Joseph,Lusinchi, Xavier,Girard, Jean-Pierre,Vidal, Jean-Pierre
, p. 1561 - 1564 (2007/10/03)
The 1-azabicyclo[5.2.0]nonan-2-one lactam 1 adequately substituted on both cycles A and B as scaffolds mimics the conformationally constrained β-turn of the tripeptide RGD signaling motif of fibronectin. Using an in vitro assay, we establish that trans di