46460-73-5

Basic information

• Product Name: N-CARBOBENZOXY-1,3-DIAMINOPROPANE HYDROCHLORIDE
• Synonyms: TIMTEC-BB SBB003190;N-Z-1,3-DIAMINOPROPANE HYDROCHLORIDE;N-CBZ-1,3-DIAMINOPROPANE HYDROCHLORIDE;N1-BENZYLOXYCARBONYL-1,3-DIAMINOPROPANE HYDROCHLORIDE;N-1-CARBOBENZOXY-1,3-DIAMINOPROPANE HYDROCHLORIDE;N-1-Z-1,3-DIAMINOPROPANE HCL;N-(3-AMINOPROPYL)CARBAMIC ACID BENZYL ESTER HYDROCHLORIDE;N-CARBOBENZOXY-1,3-DIAMINOPROPANE HYDROCHLORIDE
• CAS NO: 46460-73-5
• Molecular Formula: C₁₁H₁₆N₂O₂
• Molecular Weight: 244.72
• Mol File: 46460-73-5.mol
• Article Data: 24

Chemical Properties

• Melting Point: 185-189 °C
• Boiling Point: 368℃
• Flash Point: 177℃
• Appearance: /
• Density: 1.109
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 12.52±0.46(Predicted)
• CAS DataBase Reference: N-CARBOBENZOXY-1,3-DIAMINOPROPANE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-CARBOBENZOXY-1,3-DIAMINOPROPANE HYDROCHLORIDE(46460-73-5)
• EPA Substance Registry System: N-CARBOBENZOXY-1,3-DIAMINOPROPANE HYDROCHLORIDE(46460-73-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 3
• Hazardous Substances Data: 46460-73-5(Hazardous Substances Data)

Usage

Uses

N-Carbobenzoxy-1,3-diaminopropane, HCl

Synthesis Reference(s)

Synthesis, p. 1032, 1984 DOI: 10.1055/s-1984-31064

Upstream product

• 18807-68-6 N,N'-Dicarbobenzoxy-1,3-diaminopropan 
• 501-53-1 benzyl chloroformate 
• 109-76-2 Trimethylenediamine 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 17415-87-1 (3-phthalimido-propyl)-carbamic acid benzyl ester 
• 168827-62-1 C₂₂H₃₄N₄O₆ 
• 160291-51-0 N-(tert-butoxycarbonyl)-N'-(benzyloxycarbonyl)-1,3-propanediamine 
• 28170-07-2 benzyl phenyl carbonate 
• 177489-83-7 benzyl (3-azidopropyl)carbamate 
• 174626-34-7 N-(benzyloxycarbonyl)-3-amino-1-propyl methanesulfonate 
• 34637-22-4 3-[(N-benzyloxycarbonyl)amino]propanol 

Downstream Products

• 97614-97-6 (3-{[5-(3-Benzyloxycarbonylamino-propylcarbamoyl)-2-methyl-2H-pyrazole-3-carbonyl]-amino}-propyl)-carbamic acid benzyl ester 
• 161451-66-7 [3-(3-Benzyloxycarbonylamino-propylcarbamoyl)-propyl]-carbamic acid tert-butyl ester 
• 97614-93-2 [3-(3-Benzyloxycarbonylamino-propionylamino)-propyl]-carbamic acid benzyl ester 
• 97614-95-4 [3-(3-Benzyloxycarbonylamino-propylcarbamoyl)-propyl]-carbamic acid benzyl ester 
• 85185-25-7 N,N'-bis<3-<(benzyloxycarbonyl)amino>propyl>-3-pentanediamide 
• 98577-76-5 N,N'-bis<3-<(benzyloxycarbonyl)amino>propyl>-3-pentanediamide 
• 97614-91-0 [3-(2-Benzyloxycarbonylamino-acetylamino)-propyl]-carbamic acid benzyl ester 
• 205192-02-5 C₆₅H₇₄N₁₄O₁₂ 
• 168827-62-1 C₂₂H₃₄N₄O₆ 
• 236115-83-6 (3-{2-[(1R,2R,3S,5R,6S)-3,5-Diazido-2-((2R,3R,4R,5R,6R)-3-azido-6-azidomethyl-4,5-bis-benzyloxy-tetrahydro-pyran-2-yloxy)-6-benzyloxy-cyclohexyloxy]-ethylamino}-propyl)-carbamic acid benzyl ester 
• 586363-96-4 5-(3-benzyloxycarbonylamino-propylcarbamoyl)-3-(2-ethoxycarbonyl-ethyl)-octahydro-indole-1-carboxylic acid tert-butyl ester 
• 623929-49-7 {3-[3-(2-tert-butyloxycarbonylaminoethyl)thioureido]propyl}carbamic acid benzyl ester 
• 126849-87-4 (3-benzyloxycarbonylaminoaminopropylamino)acetic acid ethyl ester 
• 702679-42-3 1-methylethyl 2-chloro-4-[[3-[[(phenylmethoxy)carbonyl]amino]propyl]amino]pyrimidine-5-carboxylate 

Relevant articles and documents

Monoprotection of α,ω-Alkanediamines with the N-Benzyloxycarbonyl Group

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Anticancer profile and anti-inflammatory effect of new N-(2-((4-(1,3-diphenyl-1H-pyrazol-4-yl)pyridine sulfonamide derivatives

A new series of N-(2-((4-(1,3-diphenyl-1H-pyrazol-4-yl)pyridine sulfonamide derivatives 11a-o were designed and synthesized based on our previous works. The new series was tested for its anticancer and anti-inflammatory effects. The anticancer profile of

Design and synthesis of novel pyrrolo[2,3-b]pyridine derivatives targeting V600EBRAF

Several pyrrolo[2,3-b]pyridine-based B-RAF inhibitors are well known and some of them are currently FDA approved as anticancer agents. Based on the structure of these FDA approved V600EB-RAF inhibitors, two series of pyrrolo[2,3-b]pyridine scaffold were designed and synthesized in attempt to develop new potent V600EB-RAF inhibitors. The 38 synthesized compounds were biologically evaluated for their V600EB-RAF inhibitory effect at single dose (10 μM). Compounds with high percent inhibition were tested to determine their IC50 over V600EB-RAF. Compounds 34e and 35 showed the highest inhibitory effect with IC50 values of 0.085 μM and 0.080 μM, respectively. Headed for excessive biological evaluation, the synthesized derivatives were tested over sixty diverse human cancer cell lines. Only compound 35 emerged as a potent cytotoxic agent against different panel of human cancer cell lines.