587881-23-0

Basic information

• Product Name: 4(3H)-Quinazolinone, 7-chloro-2-(2-methylpropyl)-3-(phenylmethyl)-
• CAS NO: 587881-23-0
• Molecular Formula: C19H19ClN2O
• Molecular Weight: 326.826
• Mol File: 587881-23-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4(3H)-Quinazolinone, 7-chloro-2-(2-methylpropyl)-3-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(3H)-Quinazolinone, 7-chloro-2-(2-methylpropyl)-3-(phenylmethyl)-(587881-23-0)
• EPA Substance Registry System: 4(3H)-Quinazolinone, 7-chloro-2-(2-methylpropyl)-3-(phenylmethyl)-(587881-23-0)

Safety Data

• Hazardous Substances Data: 587881-23-0(Hazardous Substances Data)

Upstream product

• 13893-97-5 1-phenyl-5-methylhexane-1,3-dione 
• 476619-76-8 2-iodo-4-chlorobenzoyl chloride 
• 13421-13-1 4-chloro-2-iodobenzoic acid 
• 1256846-67-9 4-chloro-2-iodo-N-benzylbenzamide 
• 1616629-22-1 (Z)-3-amino-5-methyl-1-phenylhex-2-en-1-one 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 503-74-2 3-methylbutyric acid 
• 100-46-9 benzylamine 
• 587881-22-9 7-chloro-2-isobutyl-4H-benzo[d][1,3]oxazin-4-one 

Downstream Products

• 1417617-07-2 tert-butyl (3-(N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-3-fluorobenzamido)propyl)carbamate 
• 1417617-05-0 tert-butyl (3-(N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-4-fluorobenzamido)propyl)carbamate 
• 1417617-02-7 tert-butyl (3-(N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-4-methylbenzamido)propyl)carbamate 
• 587881-28-5 tert-butyl (3-(N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-4-methylbenzamido)propyl)carbamate 
• 336113-58-7 (S)-2-(1-amino-2-methylpropyl)-3-benzyl-7-chloroquinazolin-4(3H)-one 
• 336113-57-6 (R)-2-(1-amino-2-methylpropyl)-3-benzyl-7-chloroquinazolin-4(3H)-one 
• 336119-88-1 (±)-2-(1-amino-2-methylpropyl)-3-benzyl-7-chloroquinazolin-4(3H)-one 
• 587881-25-2 (±)-2-(1-azido-2-methylpropyl)-3-benzyl-7-chloroquinazolin-4(3H)-one 
• 1417617-03-8 tert-butyl (3-(N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-4-fluorobenzamido)propyl)carbamate 
• 1417617-01-6 tert-butyl (3-((1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)amino)propyl)carbamate 
• 587881-27-4 (R)-tert-butyl (3-((1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)amino)propyl)carbamate 
• 1314917-40-2 (±)-tert-butyl (3-((1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)amino)propyl)carbamate 
• 1314917-44-6 (±)-tert-butyl (3-(N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-4-methylbenzamido)propyl)carbamate 
• 1417617-20-9 C₂₉H₃₀ClFN₄O₂ 

Relevant articles and documents

Syntheses of quinazolinones from 2-iodobenzamides and enaminones via copper-catalyzed domino reactions

N-Substituted 2-iodobenzamides and enaminones undergo cascade transformations to achieve quinazolinones via a copper-catalyzed Ullmann-type coupling, a Michael addition and a retro-Mannich reaction. A unique stereochemical feature of this domino process was that Z-enaminones reacted without external ligands, whereas E-enaminones required the assistance of ligands. This journal is

QUINAZOLINONES

Disclosed are compounds of formula (I), wherein R, R1, R2, R3, R4, R5, R6, R7, R8, Z1, Z2, Z3, k, and Y1 have the meanings indicated in claim 1. Said compounds can be used for the treatment of tumors, among other things.