587881-28-5

Basic information

• Product Name: Carbamic acid, [3-[[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]- 2-methylpropyl](4-methylbenzoyl)amino]propyl]-, 1,1-dimethylethyl ester
• Synonyms: Carbamic acid, [3-[[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]- 2-methylpropyl](4-methylbenzoyl)amino]propyl]-, 1,1-dimethylethyl ester;(R)-[3-[[1-(3-Benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl](4-methylbenzoyl)amino]propyl]carbamic acid tert-butyl ester;(R)-tert-Butyl (3-(N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-4
• CAS NO: 587881-28-5
• Molecular Formula: C₃₅H₄₁ClN₄O₄
• Molecular Weight: 617.17744
• EINECS: -0
• Mol File: 587881-28-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.18
• CAS DataBase Reference: Carbamic acid, [3-[[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]- 2-methylpropyl](4-methylbenzoyl)amino]propyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [3-[[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]- 2-methylpropyl](4-methylbenzoyl)amino]propyl]-, 1,1-dimethylethyl ester(587881-28-5)
• EPA Substance Registry System: Carbamic acid, [3-[[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]- 2-methylpropyl](4-methylbenzoyl)amino]propyl]-, 1,1-dimethylethyl ester(587881-28-5)

Safety Data

• Hazardous Substances Data: 587881-28-5(Hazardous Substances Data)

Upstream product

• 58885-58-8 N-tert-butoxycarbonyl-3-aminopropanol 
• 58885-60-2 N-(tert-butoxycarbonyl)-3-aminopropanal 
• 336113-57-6 (R)-2-(1-amino-2-methylpropyl)-3-benzyl-7-chloroquinazolin-4(3H)-one 
• 336119-88-1 (±)-2-(1-amino-2-methylpropyl)-3-benzyl-7-chloroquinazolin-4(3H)-one 
• 587881-25-2 (±)-2-(1-azido-2-methylpropyl)-3-benzyl-7-chloroquinazolin-4(3H)-one 
• 587881-24-1 (±)-3-benzyl-2-(1-bromo-2-methylpropyl)-7-chloroquinazolin-4(3H)-one 
• 587881-23-0 3-benzyl-7-chloro-2-(2-methylpropyl)-3,4-dihydroquinazolin-4-one 
• 587881-22-9 7-chloro-2-isobutyl-4H-benzo[d][1,3]oxazin-4-one 
• 887636-73-9 C₁₂H₁₄ClNO₃ 
• 108-12-3 isopentanoyl chloride 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 587881-27-4 (R)-tert-butyl (3-((1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)amino)propyl)carbamate 
• 874-60-2 4-methyl-benzoyl chloride 

Downstream Products

• 336113-53-2 (R)-ispinesib 

Relevant articles and documents

Fluorinated quinazolinones as potential radiotracers for imaging kinesin spindle protein expression

Anti-mitotic anti-cancer drugs offer a potential platform for developing new radiotracers for imaging proliferation markers associated with the mitosis-phase of the cell-cycle. One interesting target is kinesin spindle protein (KSP) - an ATP-dependent motor protein that plays a vital role in bipolar spindle formation. In this work we synthesised a range of new fluorinated-quinazolinone compounds based on the structure of the clinical candidate KSP inhibitor, ispinesib, and investigated their properties in vitro as potential anti-mitotic agents targeting KSP expression. Anti-proliferation (MTT and BrdU) assays combined with additional studies including fluorescence-assisted cell sorting (FACS) analysis of cell-cycle arrest confirmed the mechanism and potency of these biphenyl compounds in a range of human cancer cell lines. Additional studies using confocal fluorescence microscopy showed that these compounds induce M-phase arrest via monoaster spindle formation. Structural studies revealed that compound 20-(R) is the most potent fluorinated-quinazolinone inhibitor of KSP and represents a suitable lead candidate for further studies on designing 18F-radiolabelled agents for positron-emission tomography (PET).