59050-38-3Relevant articles and documents
Lithium tert-butoxide-mediated carboxylation reactions of unprotected indoles and pyrroles with carbon dioxide
Yoo, Woo-Jin,Nguyen, Thanh V. Q.,Guiteras Capdevila, Montse,Kobayashi, Shu
, p. 1196 - 1204 (2015/04/21)
Unprotected indoles and pyrroles were found to undergo base-mediated carboxylation reactions under ambient pressure of carbon dioxide. It was found that this transition metal-free carboxylation reaction proceeded smoothly with the use of a large excess of LiOtBu.
Base-mediated carboxylation of unprotected indole derivatives with carbon dioxide
Yoo, Woo-Jin,Capdevila, Montse Guiteras,Du, Xiangwei,Kobayashi, Shu
supporting information, p. 5326 - 5329,4 (2020/09/02)
A simple and straightforward method for the preparation of indole-3-carboxylic acids was discovered through the direct carboxylation of indoles with atmospheric pressure of carbon dioxide (CO2) under basic conditions. The key for the reaction was found to be the use of a large excess of LiOtBu as a base to suppress the undesired decarboxylation side reaction.
Prototropic Generation of Dipoles. A New Synthesis of Indole-3-carboxylic Acids
Grigg, Ronald,Gunaratne, H. Q. Nimal
, p. 661 - 662 (2007/10/02)
Imines of (2-aminophenyl)acetic acid give 2-substituted indole-3-carboxylic acids under mild conditions; the cyclisation is thought to involve a 1,5-dipole and initially to give the corresponding indolines.